Amino acid derivatives, the preparation and use thereof as endothelin antagonists

ABSTRACT

The invention relates to amino acid derivatives of the formula I                    
     where the radicals have the meanings stated in the description, and to the use thereof as drugs.

The present invention relates to novel amino acid derivatives and to their preparation and use.

Endothelin is a peptide which is composed of 21 amino acids and which is synthesized and released by the vascular endothelium. Endothelin exists in three isoforms ET-1, ET-2 and ET-3. “Endothelin” or “ET” hereinafter means one or all endothelin isoforms. Endothelin is a potent vasoconstrictor and has a strong effect on vascular tone. It is known that this vasoconstriction is caused by binding of endothelin to its receptor (Nature 332 (1988) 411-415; FEBS Letters 231 (1988) 440-444, and Biochem. Biophys. Res. Commun. 154 (1988) 868-875).

Elevated or abnormal release of endothelin causes a persistent vasoconstriction in the peripheral, renal and cerebral blood vessels, which may lead to illnesses. As reported in the literature, elevated plasma endothelin levels are found in patients with hypertension, acute myocardial infarct, pulmonary hypertension, Raynaud's syndrome, atherosclerosis and in the airways of asthmatics (Japan J. Hypertension 12 (1989) 79, J. Vascular Med. Biology 2 (1990) 207, J. Am. Med. Association 264 (1990) 2868).

Accordingly, substances which specifically inhibit the binding of endothelin to the receptor ought also to antagonize the various abovementioned physiological effects of endothelin and therefore be valuable drugs.

We have found that certain amino acid derivatives are good inhibitors of endothelin receptors.

The invention relates to amino acid derivatives of the formula I

where R is formyl, tetrazolyl, cyano, COOH or a radical which can be hydrolyzed to COOH, for example R is

where R¹ has the following meanings:

a) hydrogen

b) succinimedyl

c) a 5-membered heteroaromatic ring which is linked via a nitrogen atom, such as pyrrolyl, pyrazolyl, imidazolyl and triazolyl, which can carry one or two halogen atoms or one or two C₁-C₄-alkyl or one or two C₁-C₄-alkoxy groups;

d) R¹ is furthermore

 where k can assume the values 0, 1 and 2, p can assume the values 1, 2, 3 and 4, and R⁹ is C₁-C₄-alkyl, C₃-C₇-cycloalkyl, C₃-C₆-alkenyl, C₃-C₆-alkynyl or unsubstituted or substituted phenyl which can be substituted by one or more, eg. from one to three, of the following radicals: halogen, nitro, cyano, C₁-C₄-alkyl, C₁-C₄-haloalkyl, hydroxyl, C₁-C₄-alkoxy, C₁-C₄-alkylthio, mercapto, amino, C₁-C₄-alkylamino, C₁-C₄-dialkylamino;

e) R¹ is furthermore OR¹⁰ where R¹⁰ is: hydrogen, the cation of an alkali metal such as lithium, sodium, potassium or the cation of an alkaline earth metal such as calcium, magnesium and barium, and physiologically tolerated alkylammonium ion or the ammonium ion,

C₃-C₈-cycloalkyl such as cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl or cyclooctyl,

C₁-C₈-alkyl, in particular C₁-C₄-alkyl such as methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, tert-butyl;

CH₂-phenyl which can be substituted by one or more of the following radicals: halogen, nitro, cyano, C₁-C₄-alkyl, C₁-C₄-haloalkyl, hydroxyl, C₁-C₄-alkoxy, mercapto, C₁-C₄-alkylthio, amino, C₁-C₄-alkylamino, C₁-C₄-dialkylamino,

C₃-C₆-alkenyl or C₃-C₆-alkynyl, it being possible for these groups in turn to carry from one to five halogen atoms;

R¹⁰ can furthermore be a phenyl radical which can carry from one to five halogen atoms and/or from one to three of the following radicals: nitro, cyano, C₁-C₄-alkyl, C₁-C₄-haloalkyl, hydroxyl, C₁-C₄-alkoxy, mercapto, C₁-C₄-alkylthio, amino, C₁-C₄-alkylamino, C₁-C₄-dialkylamino;

a 5-membered heteroaromatic ring which is linked via a nitrogen atom and contains from one to three nitrogen atoms and can carry one or two halogen atoms and/or one or two of the following radicals: C₁-C₄-alkyl, C₁-C₄-haloalkyl, C₁-C₄-alkoxy, phenyl, C₁-C₄-haloalkoxy and/or C₁-C₄-alkylthio, in particular 1-pyrazolyl, 3-methyl-1-pyrazolyl, 4-methyl-1-pyrazolyl, 3,5-dimethyl-1-pyrazolyl, 3-phenyl-1-pyrazolyl, 4-phenyl-1-pyrazolyl, 4-chloro-1-pyrazolyl, 4-bromo-1-pyrazolyl, 1-imidazolyl, 1-benzimidazolyl, 1,2,4-triazol-1-yl, 3-methyl-1,2,4-triazol-1-yl, 5-methyl-1,2,4-triazol-1-yl, 1-benzotriazolyl, 3,4-dichloro-1-imidazolyl;

f) R¹ is furthermore

 where R¹ is: C₁-C₄-alkyl, C₃-C₆-alkenyl, C₃-C₆-alkynyl, C₃-C₈-cycloalkyl as mentioned above in particular, it being possible for these radicals to carry a C₁-C₄-alkoxy, C₁-C₄-alkylthio and/or a phenyl radical as mentioned above;

phenyl which is unsubstituted or substituted, in particular as mentioned above;

g) R¹ is

 where R¹² has the same meaning as R¹¹;

h) R¹ can furthermore be

 where R¹³ and R¹⁴ can be identical or different and have the following meanings:

hydrogen, C₁-C₇-alkyl, C₃-C₇-cycloalkyl, C₃-C₇-alkenyl, C₃-C₇-alkynyl, benzyl, phenyl, unsubstituted or substituted, as described above,

or R¹³ and R¹⁴ together form a C₄-C₇-alkylene chain which is closed to form a ring and is unsubstituted or substituted, eg. by C₁-C₄-alkyl, and which may contain a hetero atom, eg. oxygen, nitrogen or sulfur, such as —(CH₂)₄—, —(CH₂)₅—, —(CH₂)₆—, —(CH₂)₇—, —(CH₂)₂—O—(CH₂)₂—, —(CH₂)₂—S—(CH₂)₂—, —CH₂—NH—(CH₂)₂—, —(CH₂)₂—NH—(CH₂)₂—;

a tetrazole group or a nitrile group.

The other substituents have the following meanings:

W is nitrogen or C—NO₂, and W can furthermore be a CH group when one or more of the substituents R², R³, R¹⁵ and/or R¹⁶ are nitro;

R² is hydrogen, halogen, C₁-C₄-alkyl, C₁-C₄-haloalkyl, C₁-C₄-alkoxy, C₁-C₄-haloalkoxy, hydroxyl, mercapto, C₁-C₄-alkylthio, nitro, amino, C₁-C₄-alkylamino or C₁-C₄-dialkylamino, cyano, phenyl, unsubstituted or mono- to trisubstituted by halogen, hydroxyl, amino, mono- or dialkyl-(C₁-C₃)-amino, C₁-C₃-alkyl, C₁-C₃-alkoxy, mercapto or C₁-C₃-alkylthio; or a five- or six-membered heteroaromatic ring which contains from one to three nitrogen atoms and/or one sulfur or oxygen atom and which carries from one to three substituents as described above;

R² can furthermore form with the adjacent carbon atom and X a 5- or 6-membered alkylene or alkylidene ring in which, in each case, one or two carbon atoms can be replaced by a hetero atom such as nitrogen, sulfur or oxygen, and which can be mono- to trisubstituted by the following radicals: halogen, nitro, cyano, hydroxyl, mercapto, C₁-C₃-alkyl, C₁-C₃-haloalkyl, C₁-C₃-alkoxy, C₁-C₃-alkylthio, amino, C₁-C₃-alkylamino, C₁-C₃-dialkylamino;

X is nitrogen or CR¹⁵ where R¹⁵ is hydrogen or C₁-C₅-alkyl, C₁-C₅-alkoxy, C₁-C₅-alkylthio, nitro, phenyl, hydroxyl, mercapto, halogen, amino, C₁-C₄-alkylamino, C₁-C₄-dialkylamino or cyano,

or CR¹⁵ is linked to R² to form a 5- or 6-membered ring as described above, and furthermore CR¹⁵ can form together with R³ and its adjacent carbon atom a 5- or 6-membered ring as described above;

R³ can have the same meaning as R² and furthermore form together with the adjacent carbon atom and Y a 5- or 6-membered alkylene or alkylidene ring in which, in each case, one or two carbon atoms can be replaced by nitrogen, oxygen or sulfur; the 5- or 6-membered ring can be unsubstituted or mono- to trisubstituted by the following radicals; halogen, nitro, cyano, hydroxyl, mercapto, C₁-C₃-alkyl, C₁-C₃-haloalkyl, C₁-C₃-alkoxy, C₁-C₃-alkylthio, amino, C₁-C₃-alkylamino or C₁-C₃-dialkylamino; nitrogen in the 5-membered ring can also be substituted by a formyl or acetyl group; R² and R³ can be identical or different;

Y is nitrogen or CR¹⁶ where R¹⁶ is hydrogen, C₁-C₅-alkyl, C₁-C₅-alkoxy, C₁-C₅-alkylthio, nitro, phenyl, hydroxyl, halogen, cyano, amino, C₁-C₄-alkylamino, C₁-C₄-dialkylamino or mercapto, or CR¹⁶ forms together with R³ and its adjacent carbon atom a 5- or 6-membered ring as described above;

R⁴ is hydrogen, C₁-C₇-alkyl, C₃-C₇-cycloalkyl; or phenyl or naphthyl which can be substituted by one or more of the following radicals; halogen, nitro, cyano, hydroxyl, C₁-C₄-alkyl, C₁-C₄-haloalkyl, C₁-C₄-alkoxy, C₁-C₄-haloalkoxy, phenoxy, phenyl, C₁-C₄-alkylthio, amino, C₁-C₄-alkylamino or C₁-C₄-dialkylamino,

R⁴ can also be a five- or six-membered heteroaromatic ring which contains one nitrogen, sulfur or oxygen atom and which can carry one or two of the following radicals: halogen, cyano, nitro, C₁-C₄-alkyl, C₁-C₄-haloalkyl, C₁-C₄-alkoxy, phenoxy, C₁-C₄-alkylthio, C₁-C₄-alkylamino or C₁-C₄-dialkylamino;

in addition, R⁴ and R⁵ can be phenyl groups which are connected to each other in the ortho positions by a direct linkage, a methylene, ethylene or ethenylene group, an oxygen or sulfur atom or an SO₂, NH or N-alkyl group;

R⁵ is C₁-C₇-alkyl, C₃-C₇-cycloalkyl or phenyl or naphthyl which can be substituted by from one to three of the following radicals; halogen, nitro, cyano, hydroxyl, C₁-C₄-alkyl, C₁-C₄-haloalkyl, C₁-C₄-alkoxy, C₁-C₄-haloalkoxy, phenoxy, phenyl, C₁-C₄-alkylthio, amino, C₁-C₄-alkylamino or C₁-C₄-dialkylamino, where two radicals on adjacent carbon atoms can form together with the latter, connected via an alkylene or alkylidene group, a five- or six-membered ring in which one or more —CH₂— or —CH— groups can be replaced by oxygen, for example: —(CH₂)₃—, —(CH₂)₄—, —CH═CH—O—, —O—CH₂—O—, —O—(CH₂)₂—O—, —CH═CH—CH₂— or —O—CH═CH—O—;

R⁵ can be, for example, the following radicals:

 Furthermore, R⁵ can be a five- or six-membered heteroaromatic ring which contains one nitrogen, sulfur or oxygen atom and which can carry one or two of the following radicals: halogen, cyano, nitro, C₁-C₄-alkyl, C₁-C₄-haloalkyl, C₁-C₄-alkoxy, phenoxy, C₁-C₄-alkylthio, C₁-C₄-alkylamino or C₁-C₄-dialkylamino;

in addition, R⁵ can form together with R⁴ a tricyclic system as described above, and R⁵ can additionally be an unsubstituted or substituted phenyl or heteroaromatic radical as described above which is linked in the ortho position to R⁸ to form a 6-membered ring where Q must be a single bond and R⁸ must be a CH-R¹⁷ group;

R⁶ is hydrogen, C₁-C₄-alkyl or C₁-C₄-haloalkyl

Z is a single bond, oxygen, sulfur, sulfoxide —SO— or sulfonyl;

R⁷ is hydrogen or C₁-C₄-alkyl, C₂-C₄-alkylene, C₂-C₄-alkynyl;

Q is a single bond,

a

 group

R⁸ is hydrogen, C₁-C₄-alkyl, C₂-C₄-alkylene, phenyl or benzyl, and R⁸ can furthermore be directly connected to R⁵ as described above, in which case R⁸ is a CH—R¹⁷ group where R¹⁷ is hydrogen, C₁-C₄-alkyl, phenyl or phenyl which is mono- to trisubstituted by methoxy, or is one of the following radicals

The compounds, as well as the intermediates II for preparing them, may have one or more asymmetrical substituted carbon atoms. Compounds of this type may exist as pure enantiomers or pure diastereomers or as mixture thereof. The use of an enantiomerically pure compound as active ingredient is preferred.

The invention furthermore relates to the use of the abovementioned amino acid derivatives for producing drugs, in particular for producing inhibitors of endothelin receptors.

The compounds according to the invention are prepared by reacting an amino acid derivative II with a heterocyclic derivative III where R¹⁷ is halogen or R¹⁸—SO₂, where R¹⁸ can be C₁-C₄-alkyl, C₁-C₄-haloalkyl or phenyl. In this, R is a carboxylic ester or a carboxylic acid. II with R═CO₂H is preferably used. If the preparation of II results in the amino acid ester, this is first hydrolyzed to the amino acid (R═CO₂H) by standard methods of amino acid chemistry.

The reaction preferably takes place in an inert solvent with the addition of a base, as described in the literature, eg. in J. Am. Chem Soc. 98 (1976) 8472-8475 or J. Chem. Soc. Perkin Trans I (1988) 691-696.

Examples of such solvents or diluents are water, aliphatic, alicyclic and aromatic hydrocarbons, which may be chlorinated, such as hexane, cyclohexane, petroleum ether, naphtha, benzene, toluene, xylene, methylene chloride, chloroform, carbon tetrachloride, ethyl chloride and trichloroethylene, ethers such as diisopropyl ether, dibutyl ether, methyl tert-butyl ether, propylene oxide, dioxane and tetrahydrofuran, ketones such as acetone, methyl ethyl ketone, methyl isopropyl ketone and methyl isobutyl ketone, nitriles such as acetonitrile and propionitrile, alcohols such as methanol, ethanol, isopropanol, butanol and ethylene glycol, esters such as ethyl acetate and amyl acetate, amides such as dimethylformamide and dimethylacetamide, sulfoxides and sulfones such as dimethyl sulfoxide and sulfolane, bases such as pyridine, N-methylpyrrolidone, cyclic ureas such as 1,3-dimethyl-2-imidazolidinone and 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone.

The reaction is moreover preferably carried out at a temperature in the range from 0° C. to the boiling point of the solvent or mixture of solvents.

It is possible to use as base an alkali metal or alkaline earth metal hydride such as sodium hydride, potassium hydride or calcium hydride, a carbonate such as alkali metal carbonate, eg. sodium or potassium carbonate, an alkali metal or alkaline earth metal hydroxide such as sodium or potassium hydroxide, an organo-metallic compound such as butyllithium, or an alkali metal amide such as lithium diisopropylamide.

The invention also relates to those compounds of the formula II which have not been disclosed. They can be prepared in a known manner.

The compounds IIa according to the invention, where R⁶═H and Z is a bond, can be prepared, for example, by a method described in Tetrahedron Lett. 30 (1978) 2651, by reacting a suitable imine IV with a compound V with the aid of a base in an inert solvent. This reaction is, where appropriate, carried out in a 2-phase mixture with a phase-transfer catalyst under phase-transfer conditions, for example in methylene chloride and 5-20% strength aqueous sodium hydroxide solution with a quaternary ammonium salt such as tetra-n-butylammonium bisulfate. In this, K means halogen or OR⁹ where R¹⁹ is methylsulfonyl, toluylsulfonyl or trifluoromethylsulfonyl. The imine VI is subsequently cleaved.

VI can be hydrolyzed to IIa in a suitable solvent using inorganic or organic strong acids such as hydrochloric acid, sulfuric acid, nitric acid, phosphoric acid, perchloric acid, acetic acid, trifluoromethylsulfonic acid or trifluoroacetic acid in various concentrations. Solvents which can be used are water, C₁-C₄-alcohols, acetonitrile, diethyl ether, tetrahydrofuran, dioxane or toluene. As a rule, the hydrolysis takes place in two stages. In the first step, VI is hydrolyzed with dilute acid to the amino acid ester IIa where R¹⁰≠hydrogen. Thereafter the amino acid ester is hydrolyzed with more concentrated acid or with a strong acid to the amino acid IIa where R¹⁰=H.

Reaction of compound IIa with III as described above results in compounds Ia according to the invention where R⁶ is hydrogen, R⁸ is hydrogen and Z and Q are each a single bond.

The compounds IIb according to the invention where Z is a bond, R⁵ is an aromatic or heteroaromatic radical and R⁶ is a C₁-C₄-alkyl group are prepared by reacting a suitable phosphonate compound VII with a carbonyl compound VIII in a Wittig-Horner reaction to give the α,β-unsaturated compound IX

where R²⁰ is C₁-C₆-alkyl or benzyl.

Compound IX can be converted into the carboxylic acid derivative X by a method from Chem. Ber. 64 (1931) 1493 et seq. using R⁵—H with the aid of a Friedel-Crafts catalyst such as aluminum trichloride.

Compounds X can be converted by known methods into hydrazino acid derivatives XII as described, for example, in J. Am. Chem. Soc., 108 (1986) 6395-6397. The aminating reagent used is dialkyl azodicarboxylate XI where R²¹ is 2,2-dimethylethyl or benzyl.

Hydrolysis of XII with a strong inorganic or organic acid in a suitable solvent as described above leads to the α-hydrazino carboxylic acid derivative XIII. If R²¹ is benzyl, the conversion of XII into XIII can also take place by hydrogenolysis with hydrogen and a suitable catalyst such as palladium on active carbon of various concentrations, for example 10% palladium on carbon.

α-Hydrazino carboxylic acid derivatives XIII can be reduced with hydrogen under pressure, eg. 10-50 bar, with a suitable catalyst, eg. Raney nickel, to the α-amino acid derivatives IIb.

Compounds IIb can be reacted with III to give the compounds Ib according to the invention as described above.

Compounds IIb can also be prepared by reacting a compound XIV with a Grignard compound XV, and hydrolyzing the product XVI with acid to IIb, similar to the description in Liebigs Ann. (1977) 1174-1182:

The compounds IIc according to the invention where R⁶ is C₁-C₄-alkyl, and Z is oxygen, sulfur, S═O or SO₂, can be prepared by opening a suitable aziridine XVII with an alcohol or thiol R⁶—Z—H to give XVIII.

This method is described, for example, in J. Chem. Soc. Perkin Trans. II (1981) 121-126. Subsequent oxidation, eg. with metachloroperbenzoic acid in a suitable solvent, in the case where Z=sulfur provides the corresponding compounds XVIII with Z═SO or SO₂ depending on the molar ratio of the components. R²² is hydrogen or a suitable protective group such as benzyl, benzyloxycarbonyl, tert-butyloxycarbonyl. If R²² is hydrogen, then XVIII corresponds to IIc. When R²²≠hydrogen, the protective group must be removed by known methods of hydrolysis, with addition of acid, or hydrogenolysis with a suitable catalyst to result in compound lIe in this way. The compounds IIc according to the invention can be reacted as described above with III to give Ic.

Compounds XVII, which are likewise according to the invention, can be prepared by reacting α,β-unsaturated carbonyl compounds XIX which are known or have been prepared by known methods with an aminating reagent XX and a suitable catalyst, for example as disclosed in J. Org. Chem. 56 (1991) 6744-6.

The compounds Id according to the invention where Q is a bond and R⁸ is not hydrogen can be prepared by converting an amino acid derivative IId (Q is a bond and R⁸ is hydrogen) by known methods for example into an N-benzyloxycarbonyl derivative XXI and reacting the latter

in an inert solvent, eg. tetrahydrofuran, with a strong base, eg. potassium tert-butoxide, and an alkylating agent R⁸—K where K is normally halogen or sulfate. The derivative XXII resulting from this can be deprotected by known methods to give the amino compound IIe, for example by eliminating the benzyloxycarbonyl group with hydrogen with catalysis by palladium/active carbon in an inert solvent.

IIe is then reacted with III to give compounds Id as described above.

The compounds Ie according to the invention where Q is a

group can be prepared, for example, by reacting

compounds Ia-d with XXIII under basic conditions in an inert solvent to give Ie.

In this, L is halogen, OR²³ where R²³ is one of the following radicals: C₁-C₄-alkyl, benzyl, succinimidyl or 2,4,5-trichlorophenyl; L can also be azido, p-tolylsulfonyl, methylsulfonyl, trifluoromethylsulfonyl or an anhydride moiety.

The compounds If according to the invention where R⁵ is linked to R⁸ can be prepared from the tetrahydroisoquinoline derivatives IIf, which in turn can be prepared from the amino acid derivatives IId by reacting with aldehydes of the structure XXIV in the presence of acid, eg. hydrochloric acid or sulfuric acid, similar to Synthesis (1990) 550-556.

A {circumflex over (═)} aromatic or heteroaromatic system, unsubstituted or substituted

IIf is then reacted with III to give compound If as described above.

Compounds of the formula I can be obtained in enantiomerically pure form by starting from enantiomerically pure compounds II which can be prepared in enantiomerically pure and, where appropriate, diastereomerically pure form by classical racemate resolution or by enantioselective syntheses (eg. Pure Appl. Chem. 55 (1983) 1799 et seq.; Helv. Chim. Acta 71 (1988) 224 et seq.; J. Am. Chem. Soc, 110 (1988) 1547-1557; Chem. Eng. News (1989) 25-27), and reacting these compounds II with III as described above. Another possibility for obtaining enantiomerically pure compounds of the formula I is classical racemate resolution of racemic or diastereomeric compounds I with suitable enantiomerically pure bases such as brucine, strychnine, quinine, quinidine, cinchonidine, cinchonine, yohimbine, morphine, dehydroabietylamine, ephedrine (−), (+), deoxyephedrine (+), (−), threo-2-amino-1-(p-nitrophenyl)-1,3-propanediol (+), (−), threo-2-(N,N-dimethylamino)-1-(p-nitrophenyl)-1,3-propanediol (+), (−) threo-2-amino-1-phenyl-1,3-propanediol (+), (−), α-methylbenzylamine (+), (−), α-(1-naphthyl)ethylamine (+), (−), α-(2-naphthyl)ethylamine (+), (−), aminomethylpinone, N,N-dimethyl-1-phenylethylamine, N-methyl-1-phenylethylamine, 4-nitrophenylethylamine, pseudoephedrine, norephedrine, norpseudoephedrine, amino acid derivatives and peptide derivatives.

Preferred compounds of the formula I, both as pure enantiomers and pure diastereomers or as mixture thereof, are those in which the substituents have the following meanings:

R is a carboxylic acid, a carboxylic acid salt or a group which can be hydrolyzed to a carboxylic acid, as described above.

R² is hydrogen, halogen, C₁-C₄-alkyl, C₁-C₄-haloalkyl, nitro, C₁-C₄-alkoxy, C₁-C₅-alkylthio, cyano, amino, methylamino, hydroxyl or dimethylamino;

W is nitrogen, C—NO₂, also CH when at least one of the radicals R², R³, R¹⁵ and R¹⁶ is a nitro group;

X is nitrogen or CR¹⁵ where R¹⁵ is hydrogen, C₁-C₄-alkyl, C₁-C₄-alkoxy, nitro, cyano, halogen or phenyl, or CR¹⁵ forms with R³ and the adjacent carbon atom a 5- or 6-membered alkylene or alkylidene ring in which one or two carbon atoms can be replaced by a hetero atom such as nitrogen, oxygen or sulfur, and which can be mono- or disubstituted by a C₁-C₃-alkyl (or C₁-C₃-alkoxy group); nitrogen in a 5-membered ring may additionally be substituted by a CHO or COCH₃ group;

R³ can have the same meaning as R² and additionally form with X and the adjacent carbon atom an unsubstituted or substituted 5- or 6-membered ring as described above; R³ can furthermore form with the adjacent carbon atom and Y a 5- or 6-membered alkylene or alkylidene ring in which one or two carbon atoms can be replaced by nitrogen, oxygen or sulfur and which can be mono- or disubstituted by a C₁-C₃-alkyl or C₁-C₃-alkoxy group, and a nitrogen atom in a 5-membered ring can be substituted by a CHO or COCH₃ group;

R⁴ has the meaning of hydrogen, C₁-C₆-alkyl, C₃-C₇-cycloalkyl or phenyl which can be substituted by one or more of the following radicals: halogen, C₁-C₄-alkyl, C₁-C₄-alkoxy, phenyl, furthermore R⁴ and R⁵ can be phenyl groups which are connected to each other in the ortho positions by a direct linkage, a CH₂ group, a CH₂—CH₂ group or an oxygen atom;

R⁵ can have the same meaning as R⁴ apart from hydrogen and C₁-C₆-alkyl, R⁵ can additionally be phenyl which can be substituted exclusively or in addition to the abovementioned radicals by two radicals on adjacent carbon atoms, which together represent a 1,3-dioxomethylene or 1,4-dioxoethylene group and form with the adjacent carbon atoms a 5- or 6-membered ring;

R⁶ is hydrogen or C₁-C₄-alkyl;

Z is a single bond, oxygen or sulfur;

R⁷ is hydrogen or C₁-C₄-alkyl;

Q is single bond, a carbonyl group or an oxycarbonyl group;

R⁸ is hydrogen or C₁-C₄-alkyl.

Particularly preferred compounds of the formula I, both as pure enantiomers or pure diastereomers or as mixture thereof, are those in which the substituents have the following meanings:

R is a carboxylic acid, a carboxylic acid salt or a group which can be hydrolyzed to a carboxylic acid, as described above;

R² is hydrogen, chlorine, methyl, ethyl, CF₃, nitro, methoxy, ethoxy, hydroxyl, methylthio, amino, N-methylamino or dimethylamino;

W is nitrogen;

X is nitrogen or CR¹⁵ where R¹⁵ is hydrogen, methyl, nitro or cyano, or CR¹⁵ forms with R³ and the adjacent carbon atom a 5- or 6-membered alkylene or alkylidene ring in which one carbon atom can be replaced by oxygen, and which can be substituted by a methyl or methoxy group; the 5- or 6-membered alkylene or alkylidene ring can have the following structures, for example:

R³ can have the same meaning as R² and additionally form with X and the adjacent carbon atom an unsubstituted or substituted 5- or 6-membered ring as described above; R³ can furthermore form with the adjacent carbon atom a substituted or unsubstituted 5- or 6-membered alkylene or alkylidene ring in which one or two carbon atoms can be replaced by nitrogen or oxygen and which can be substituted by a methyl or methoxy group; examples of such alkylene or alkylidene rings are:

R⁴ has the meaning of hydrogen, methyl, ethyl, n-propyl, 1-methylethyl, cyclohexyl, or phenyl which can be substituted by one or two methoxy groups, furthermore R⁴ and R⁵ can be phenyl groups which are connected to each other in the ortho positions by a direct linkage, a CH₂ or CH₂-CH₂ group;

R⁵ is cyclohexyl or phenyl which can be substituted by phenyl, one to three methoxy groups, or exclusively or in addition to a methoxy group by two radicals on adjacent carbon atoms which together represent a 1,3-dioxomethylene or 1,4-dioxoethylene group and form with the adjacent carbon atoms a 5- or 6-membered ring, R⁵ can additionally be an unsubstituted or substituted phenyl ring which is linked in the ortho position to R⁸ to form a 6-membered ring when Q is a single bond and R⁸ is a CH—R¹⁷ group;

R⁶ is hydrogen, methyl, ethyl, n-propyl or 1-methylethyl;

R⁷ is hydrogen or methyl;

Q is a single bond, a carbonyl group or an oxycarbonyl group;

R⁸ is hydrogen, methyl or 1,1-dimethylethyl, R⁸ can additionally be directly connected to R⁵ as described above when R⁸ is a CH—R¹⁷ group in which R¹⁷ is hydrogen, methyl, ethyl, phenyl or phenyl which is mono- to trisubstituted by methoxy, or one of the following radicals:

The compounds of the present invention provide a novel therapeutic potential for the treatment of hypertension, pulmonary hypertension, myocardial infarct, angina pectoris, acute kidney failure, renal insufficiency, cerebral vasospasms, cerebral ischemia, subarachnoid hemorrhages, migraine, asthma, atherosclerosis, endotoxic shock, endotoxin-induced organ failure, intravascular coagulation, restenosis following angioplasty, benign prostate hyperplasia, ischemic kidney failure and that caused by intoxication, and hypertension.

The good effect of the compounds can be shown in the following tests:

Receptor Binding Studies

Cloned human ETA receptor-expressing CHO cells and guinea-pig cerebellar membranes with >60% ET_(B) by comparison with ET_(A) receptors were used for the binding studies.

Membrane Preparation

The ET_(A) receptor-expressing CHO cells were grown in F₁₂ medium containing 10% fetal calf serum, 1% glutamine, 100 U/ml penicillin and 0.2% streptomycin (Gibco BRL, Gaithersburg, Md., USA). After 48 h, the cells were washed with PBS and incubated with 0.05% trypsin-containing PBS for 5 min. The F₁₂ medium was then neutralized, and the cells were collected by centrifugation at 300×g. To lyse the cells, the pellet was briefly washed with lysis buffer (5 mM tris-HCl, pH 7.4 with 10% glycerol) and then incubated at a concentration of 10⁷ cells/ml of lysis buffer at 4° C. for 30 min. The membranes were centrifuged at 20,000×g for 10 min, and the pellet was stored in liquid nitrogen.

Guinea-pig cerebella were homogenized in a Potter-Elvejhem homogenizer and obtained by differential centrifugation at 1,000×g for 10 min and repeated centrifugation of the supernatant at 20,000×g for 10 min.

Binding Assays

For the ET_(A) and ET_(B), receptor binding assays, the membranes were suspended in incubation buffer (50 mM tris-HCl, pH 7.4 with 5 mM MnCl₂, 40 μg/ml bacitracine and 0.2% BSA) at a concentration of 50 μg of protein per assay mixture, and incubated with 25 pM ¹²⁵I-ET₁, (ET_(A) receptor assay) or 25 pM ¹²⁵I-RZ₃ (ET_(B) receptor assay) at 25° C. in the presence and absence of test substance. The non-specific binding was determined using 10⁻⁷ M ET₁. After 30 min, the free and bound radioligand were separated by filtration through GF/B glass fiber filters (Whatman, England) on a Skatron cell collector (Skatron, Lier, Norway), and the filters were washed with ice-cold tris-HCl buffer, pH 7.4 with 0.2% BSA. The radioactivity collected on the filters was quantified using a Packard 2200 CA liquid scintillation counter.

Functional in vitro assay system for searching for endothelin receptor (subtype A) antagonists

This assay system is a functional, cell-based assay for endothelin receptors. When certain cells are stimulated with endothelin 1 (ET1) they show an increase in the intracellular calcium concentration. This increase can be measured in intact cells loaded with calcium-sensitive dyes.

Fibroblasts which had been isolated from rats and in which an endogenous endothelin receptor of subtype A had been detected were loaded with the fluorescent dye Fura 2-an as follows: After trypsinization, the cells were resuspended in buffer A (120 mM NaCl, 5 mM KCl, 1.5 mM MgCl₂, 1 mM CaCl₂, 25 mM HEPES, 10 mM glucose, pH 7.4). to a density of 2×10⁶/ml and incubated with Fura 2-am (2 μM), Pluronic F-127 (0.04%) and DMSO (0.2%) at 37° C. in the dark for 30 min. The cells were then washed twice with buffer A and resuspended at 2×10⁶/ml.

The fluorescence signal from 2×10⁵ cells per ml with Ex/Em 380/510 was recorded continuously at 30° C. To the cells were added the test substances and after an incubation time of 3 min ET1. The maximum change in fluorescence was determined over 30 minutes. The response of the cells to ET1 without previous addition of a test substance served as control and was set equal to 100%.

In vivo Testing of ET Antagonists

Male SD rats weighing 250-300 g were anesthetized with amobarbital, artifically ventilated, vagotomized and pithed. The carotid artery and jugular vein were cathetized.

Intravenous administration of 1 μg/kg ET1 to control animals leads to a marked rise in blood pressure which persists for a lengthy period.

The test compounds were injected i.v. (1 ml/kg) into the test animals 5 min before ET1 administration. To determine the ET-antagonistic properties, the rise in blood pressure in the test animals was compared with that in the control animals.

Sudden Death of Mice Induced by Endothelin-1

The principle of the test is the inhibition of the sudden heart death of mice caused by endothelin, probably owing to constriction of the coronary vessels, by pretreatment with endothelin receptor antagonists. Intravenous injection of 10 nmol/kg endothelin in a volume of 5 ml/kg of body weight is followed within a few minutes by the death of the animals.

The lethal dose of endothelin-1 is checked in each case on a small group of animals. Intravenous administration of the test substance is usually followed after 5 min by the injection of endothelin-1 which was lethal in the reference group. The times before administration increase with other modes of administration, possibly up to several hours.

The survival rate is recorded, and effective doses which protect 50% of the animals from endothelin-induced heart death for 24 h or longer (ED 50) are determined.

Functional Test on Vessels for Endothelin Receptor Antagonists

First a contraction is induced by K⁺ in segments of rabbit aorta after a previous tension of 2 g and a relaxation time of 1 h in Krebs-Henseleit solution at 37° C. and pH 7.3-7.4. Washing out is followed by construction of an endothelin dose-effect plot up to the maximum.

Potential endothelin antagonists are administered to other preparations of the same vessel 15 min before starting the endothelin dose-effect plot. The effects of endothelin are calculated as a % of the K⁺-induced contraction. Effective endothelin antagonists result in a shift in the endothelin dose-effect plot to the right.

The compounds according to the invention can be administered orally or parenterally (subcutaneously, intravenously, intramuscularly, intraperitoneally) in a conventional way. Administration can also take place with vapors or sprays through the nasopharyngeal space.

The dosage depends on the age, condition and weight of the patient and on the mode of administration. As a rule, the daily dose of active ingredient is about 0.5-50 mg/kg of body weight on oral administration and about 0.1-10 mg/kg of body weight on parenteral administration.

The novel compounds can be used in conventional solid or liquid pharmaceutical forms, eg. as uncoated or (film-)coated tablets, capsules, powders, granules, suppositories, solutions, ointments, creams or sprays. These are produced in a conventional way. For this purpose the active ingredients can be processed with conventional pharmaceutical aids such as tablet binders, bulking agents, preservatives, tablet disintegrants, flow regulators, plasticizers, wetting agents, dispersants, emulsifiers, solvents, release-slowing agents, antioxidants and/or propellent gases (cf. H. Sucker et al.: Pharmazeutische Technologie, Thieme-Verlag, Stuttgart, 1991). The administration forms obtained in this way normally contain from 0.1 to 90% by weight of active ingredient.

SYNTHESIS EXAMPLES Example 1 Di(3-methoxyphenyl)methyl bromide

22.53 g (92.9 mmol) of di(m-methoxyphenyl)methyl alcohol were dissolved in 200 ml of diethyl ether and, under a nitrogen atmosphere, 28.76 g (138.3 mmol) of thionyl bromide dissolved in 20 ml of diethyl ether were added dropwise. After 6 hours at room temperature, the mixture was poured into ice-water, and the organic phase was separated off, washed with water and saturated NaHCO₃ solution, then dried with MgSO₄ and concentrated. 27.73 g (97.8%) of crude product were obtained and were immediately reacted further.

Example 2 Methyl 2-N-(diphenylmethylene)amino-3,3-di(3-methoxyphenyl)propionate

19.05 g (75.2 mmol) of N-diphenylmethylenylglycine methyl ester were dissolved in 200 ml of THF and, at −78° C. under an argon atmosphere, 75 ml of a 1.5 molar solution of LDA in THF were slowly added dropwise. After 45 minutes, 27.73 g (90.3 mmol) of di(3-methoxyphenyl)methyl bromide in 60 ml of THF were added dropwise. After 90 minutes, the mixture was allowed to reach room temperature and was then stirred for 22 hours. Then 20 ml of phosphate buffer were added, the THF was stripped off under reduced pressure, and the residue was extracted three times with ethyl acetate. The combined organic phases were dried with MgSO₄ and concentrated. 43.3 g of crude product were obtained and were immediately reacted further.

Example 3 Methyl 2-amino-3,3-di(3-methoxyphenyl)propionate

43.3 g (75.2 mmol) of methyl 2-N-(diphenylmethylene)amino-3,3-di(3-methoxyphenyl)propionate (crude product) were dissolved in 1 1 of THF and, after addition of 506 ml of 0.5 normal hydrochloric acid, stirred at room temperature for 90 minutes. After the THF had been stripped off under reduced pressure, the aqueous residue was extracted with ethyl acetate. The aqueous phase was then made alkaline (pH 9-10) with 25% strength ammonia solution.

The aqueous phase was then extracted four times with ethyl acetate. The combined organic phases were dried with MgSO₄ and concentrated. 14.27 g (60.1%) of product were obtained.

Example 4 2-Amino-3,3-di(3-methoxyphenyl)propionic acid

6.0 g (19.0 mmol) of methyl 2-amino-3,3-di(3-methoxyphenyl)propionate were refluxed in 140 ml of 6 normal hydrochloric acid for 6 hours. The mixture was then cooled to 0° C., and the precipitate was filtered off, washed with water and dried. The solid was then dissolved in 50 ml of ethanol, 20 ml of propene oxide were added and the mixture was refluxed for 30 minutes. After cooling, the precipitate was filtered off, washed with ethanol and dried. 2.20 g (38.4%) of a white powder of melting piont 168-173° C. were obtained.

Example 5 3,3-Di(3-methoxyphenyl)-2-(4,6-dimethoxy-2-pyrimidinylamino)-propionic acid

2.20 g (7.3 mmol) of 2-amino-3,3-di(3-methoxyphenyl)propionic acid, 0.66 g (3.04 mmol) of 4,6-dimethoxy-2-methylsulfonylpyrimidine and 0.39 g (3.65 mmol) of sodium carbonate were introduced into a mixture of 16 ml of DMF and 16 ml of water and stirred at 80° C. for 10 hours. Water and ethyl acetate were then added to the reaction mixture. The aqueous phase was acidified with 6 normal hydrochloric acid and extracted three times with ethyl acetate. Drying with MgSO₄ and concentration resulted in the crude product, which was chromatographed on silica gel with dichloromethane/methanol (50:1). 0.455 g (34.1%) of a white powder of melting point 58-66° C. was obtained.

Example 6 3,3-Diphenyl-2-(4,6-dimethyl-2-pyrimidinylamino)propionic acid

2.60 g (10.8 mmol) of 2-amino-3,3-diphenylpropionic acid and 0.64 g (4.5 mmol) of 2-chloro-4,6-dimethylpyrimidine were introduced into a mixture of 16 ml of DMF and 16 ml of water, 0.57 g (5.4 mmol) of sodium carbonate was added and the mixture was stirred at 80° C. for 24 hours. Then 100 ml of ethyl acetate and a little water were added, and the phases were separated. The aqueous phase was acidified (pH 1-2) with 6 normal hydrochloric acid. The resulting precipitate was filtered off with suction and washed with ethyl acetate, then dried. 0.30 g (19.2%) of a white powder of melting point 172-174° C. was obtained.

Example 7 2-(4,6-Dimethoxy-2-triazinylamino)-2-(9-fluorenyl)acetic acid

2.29 g (9.6 mmol) of 2-amino-2-(9-fluorenyl)acetic acid, 0.70 g (4.0 mmol) of 4,6-dimethoxy-2-chlorotriazine and 0.51 g (4.8 mmol) of sodium carbonate were introduced into a mixture of 16 ml of DMF and 16 ml of water and stirred at 80° C. for 13 hours. Then ethyl acetate and water were added and the phases were separated. The aqueous phase was acidified with 6 normal HCl and extracted three times with ethyl acetate. The organic phases were dried with MgSO₄ and concentrated. The crude product was chromatographed on silica gel with ethyl acetate/n-heptane (1:1). 0.44 g (29.1%) of a white powder was obtained; R_(F)=0.135, melting point 182-186° C.

Example 8 2-(3-Nitro-6-methoxy-2-pyridinylamino)-3,3-diphenylpropionic acid

2.50 g (10.4 mmol) of 2-amino-3,3-diphenylpropionic acid, 0.84 g (4.3 mmol) of 2-chloro-3-nitro-6-methoxypyridine and 0.55 g (5.2 mmol) of sodium carbonate were introduced into 18 ml of DMF and 18 ml of water, and the mixture was stirred at 80° C. for 5 hours. Ethyl acetate and water were then added, and the phases were separated. The aqueous phase was acidified with 6 normal hydrochloric acid and extracted three times with ethyl acetate. After drying with MgSO₄ and concentration under reduced pressure, the crude product was recrystallized from isopropanol. 0.34 g (20.1%) of a yellow powder of melting point 172-180° C. was obtained.

The examples listed in following Tables 1-5 can be prepared by the methods described at the outset.

TABLE 1 (I)

No. R⁴ R⁵ R⁷ R² X R³ Y M.p. [° C.] I-1 H Phenyl H Me CH Me N I-2 H Phenyl H OMe CH Me N I-3 H Phenyl H Me CH Me N I-4 H Phenyl H Me CH Et N I-5 H Phenyl H Et CH Et N I-6 H Phenyl H CF₃ CH Me N I-7 H Phenyl H CF₃ CH OMe N I-8 H Phenyl H Me C—(CH₂)₃ — N I-9 H Phenyl H OMe C—(CH₂)₃ — N I-10 H Phenyl H OMe C—(CH₂)₂ O N I-11 H Phenyl H OMe N OMe N I-12 H Phenyl H OMe N Me N I-13 H Phenyl H OMe N OMe N I-14 H Phenyl Me OMe CH OMe CH I-15 H Phenyl Me OMe CH Me N I-16 H Phenyl Me OMe CH N═C N I-17 H Phenyl H OMe N H —NH—C I-18 H Phenyl H OMe N H C—NO₂ I-19 H Phenyl H OMe C—Me OMe N I-20 H Phenyl H OMe CH Me N 188-193 I-21 H Phenyl H H N NH₂ CH I-22 H Phenyl H H N H N I-23 H Phenyl H H CH OMe N I-24 Me Phenyl H OMe CH OMe N I-25 Me Phenyl H OMe CH Me N I-26 Me Phenyl H Me CH Me N I-27 Me Phenyl H Me CH Et N I-28 Me Phenyl H Et CH Et N I-29 Me Phenyl H Me CH CF₃ N I-30 Me Phenyl H OMe CH CF₃ N I-31 Me Phenyl H Me C—(CH₂)₃— N I-32 Me Phenyl H OMe C—(CH₂)₃— N I-33 Me Phenyl H OMe C—(CH₂)₃—O N I-34 Me Phenyl H Me C—(CH₂)₃—O N I-35 Me Phenyl H OMe N OMe N I-36 Me Phenyl H OMe CH H N I-37 Me Phenyl H OMe N OMe CH I-38 Me Phenyl H Cl N Me CH I-39 Me Phenyl H Me N Me CH I-40 Me Phenyl H OMe N N═CH—NH—C I-41 Me Phenyl H Cl N N═CH—NH—C I-42 Me Phenyl H OMe N H C—NO₂ I-43 Me Phenyl H OMe C—Me H N I-44 Me Phenyl H Me C—Me H N I-45 Me Phenyl H NH₂ N NH₂ N I-46 Me Phenyl H NHCH₃ N NHCH₃ N I-47 Me Phenyl H SMe CH H N I-48 Me Phenyl Me OMe CH OMe N I-49 Me Phenyl Me OMe CH Me N I-50 Me Phenyl Me Me CH Me N I-51 Et Phenyl H OMe CH OMe N I-52 Et Phenyl H OMe CH Me N I-53 Et Phenyl H Me CH Me N I-54 Et Phenyl H Me CH Et N I-55 Et Phenyl H Et CH Et N I-56 Et Phenyl H Me CH CF₃ N I-57 Et Phenyl H OMe CH CF₃ N I-58 Et Phenyl H OMe CH H N I-59 Et Phenyl H SMe CH H N I-60 Et Phenyl H Et CH OMe N I-61 Et Phenyl H Me C—(CH₂)₃— N I-62 Et Phenyl H OMe C—(CH₂)₃— N I-63 Et Phenyl H Me C—(CH₂)₂—O N I-64 Et Phenyl H OMe C—(CH₂)₂—O N I-65 Et Phenyl H OMe N OMe N I-66 Et Phenyl H NH₂ N NH₂ N I-67 Et Phenyl H NHMe N NHMe N I-68 Et Phenyl H OMe N OMe CH I-69 Et Phenyl H Me N Me CH I-70 Et Phenyl H Cl N Me CH I-71 Et Phenyl H OMe N N═CH—NH—C I-72 Et Phenyl H Cl N N═CH—NH—C I-73 Et Phenyl H OMe N H C—NO₂ I-74 Et Phenyl H OMe C—Me H N I-75 Et Phenyl H Me C—Me H N I-76 Et Phenyl Me OMe CH OMe N I-77 Et Phenyl Me OMe CH Me N I-78 Et Phenyl Me Me CH Me N I-79 H 4-Methoxyphenyl H OMe CH OMe N I-80 H 4-Methoxyphenyl H OMe CH Me N I-81 H 4-Methoxyphenyl H Me CH Me N I-82 H 4-Methoxyphenyl H Me CH Et N I-83 H 4-Methoxyphenyl H Et CH Et N I-84 H 4-Methoxyphenyl H Me CH CF₃ N I-85 H 4-Methoxyphenyl H OMe CH CF₃ N I-86 H 4-Methoxyphenyl H OMe CH H N I-87 H 4-Methoxyphenyl H SMe CH H N I-88 H 4-Methoxyphenyl H Et CH OMe N I-89 H 4-Methoxyphenyl H Me C—(CH₂)₃— N I-90 H 4-Methoxyphenyl H OMe C—(CH₂)₃— N I-91 H 4-Methoxyphenyl H Me C—(CH₂)₂—O N I-92 H 4-Methoxyphenyl H OMe C—(CH₂)₂—O N I-93 H 4-Methoxyphenyl H OMe N OMe N I-94 H 4-Methoxyphenyl H NH₂ N NH₂ N I-95 H 4-Methoxyphenyl H NHMe N NHMe N I-96 H 4-Methoxyphenyl H OMe N OMe CH I-97 H 4-Methoxyphenyl H Cl N Me CH I-98 H 4-Methoxyphenyl H OMe N N═CH—NH—C I-99 H 4-Methoxyphenyl H Cl N N═CH—NH—C I-100 H 4-Methoxyphenyl H Me N Me CH I-101 H 4-Methoxyphenyl H OMe N Me CH I-102 H 4-Methoxyphenyl H OMe N H C—NO₂ I-103 H 4-Methoxyphenyl H OMe C—Me H N I-104 H 4-Methoxyphenyl H Me C—Me H N I-105 H 4-Methoxyphenyl Me OMe CH OMe N I-106 H 4-Methoxyphenyl Me OMe CH Me N I-107 H 4-Methoxyphenyl Me Me CH Me N I-108 H 3-Methoxyphenyl H OMe CH OMe N I-109 H 3-Methoxyphenyl H OMe CH Me N I-110 H 3-Methoxyphenyl H Me CH Me N I-111 H 3-Methoxyphenyl H Me CH Et N I-112 H 3-Methoxyphenyl H Et CH Et N I-113 H 3-Methoxyphenyl H Me CH CF₃ N I-114 H 3-Methoxyphenyl H OMe CH CF₃ N I-115 H 3-Methoxyphenyl H OMe CH H N I-116 H 3-Methoxyphenyl H SMe CH H N I-117 H 3-Methoxyphenyl H Et CH OMe N I-118 H 3-Methoxyphenyl H Me C—(CH₂)₃— N I-119 H 3-Methoxyphenyl H OMe C—(CH₂)₃— N I-120 H 3-Methoxyphenyl H Me C—(CH₂)₂—O N I-121 H 3-Methoxyphenyl H OMe C—(CH₂)₂—O N I-122 H 3-Methoxyphenyl H OMe N OMe N I-123 H 3-Methoxyphenyl H NH₂ N NH₂ N I-124 H 3-Methoxyphenyl H NHMe N NHMe N I-125 H 3-Methoxyphenyl H OMe N OMe CH I-126 H 3-Methoxyphenyl H Cl N Me CH I-127 H 3-Methoxyphenyl H OMe N N═CH—NH—C I-128 H 3-Methoxyphenyl H Cl N N═CH—NH—C I-129 H 3-Methoxyphenyl H Me N Me CH I-130 H 3-Methoxyphenyl H OMe N Me CH I-131 H 3-Methoxyphenyl H OMe N H C—NO₂ I-132 H 3-Methoxyphenyl H OMe C—Me H N I-133 H 3-Methoxyphenyl H Me C—Me H N I-134 H 3-Methoxyphenyl Me OMe CH OMe N I-135 H 3-Methoxyphenyl Me OMe CH Me N I-136 H 3-Methoxyphenyl Me Me CH Me N I-137 H 3,4-Dimethoxyphenyl H OMe CH OMe N I-138 H 3,4-Dimethoxyphenyl H OMe CH Me N I-139 H 3,4-Dimethoxyphenyl H Me CH Me N I-140 H 3,4-Dimethoxyphenyl H Me CH Et N I-141 H 3,4-Dimethoxyphenyl H Et CH Et N I-142 H 3,4-Dimethoxyphenyl H Me CH CF₃ N I-143 H 3,4-Dimethoxyphenyl H OMe CH CF₃ N I-144 H 3,4-Dimethoxyphenyl H OMe CH H N I-145 H 3,4-Dimethoxyphenyl H SMe CH H N I-146 H 3,4-Dimethoxyphenyl H Et CH OMe N I-147 H 3,4-Dimethoxyphenyl H Me C—(CH₂)₃— N I-148 H 3,4-Dimethoxyphenyl H OMe C—(CH₂)₃— N I-149 H 3,4-Dimethoxyphenyl H Me C—(CH₂)₂—O N I-150 H 3,4-Dimethoxyphenyl H OMe C—(CH₂)₂—O N I-151 H 3,4-Dimethoxyphenyl H OMe N OMe N I-152 H 3,4-Dimethoxyphenyl H NH₂ N NH₂ N I-153 H 3,4-Dimethoxyphenyl H NHMe N NHMe N I-154 H 3,4-Dimethoxyphenyl H OMe N OMe CH I-155 H 3,4-Dimethoxyphenyl H Cl N Me CH I-156 H 3,4-Dimethoxyphenyl H OMe N N═CH—NH—C I-157 H 3,4-Dimethoxyphenyl H Cl N N═CH—NH—C I-158 H 3,4-Dimethoxyphenyl H Me N Me CH I-159 H 3,4-Dimethoxyphenyl H OMe N Me CH I-160 H 3,4-Dimethoxyphenyl H OMe N H C—NO₂ I-161 H 3,4-Dimethoxyphenyl H OMe C—Me H N I-162 H 3,4-Dimethoxyphenyl H Me C—Me H N I-163 H 3,4-Dimethoxyphenyl Me OMe CH OMe N I-164 H 3,4-Dimethoxyphenyl Me OMe CH Me N I-165 H 3,4-Dimethoxyphenyl Me Me CH Me N I-166 H 3,4(1,3-Dioxomethy- H OMe CH OMe N 228-235 lene)phenyl (decomp.) I-167 H 3,4(1,3-Dioxomethy- H OMe CH Me N lene)phenyl I-168 H 3,4(1,3-Dioxomethy- H Me CH Me N lene)phenyl I-169 H 3,4(1,3-Dioxomethy- H Me CH Et N lene)phenyl I-170 H 3,4(1,3-Dioxomethy- H Et CH Et N lene)phenyl I-171 H 3,4(1,3-Dioxomethy- H Me CH CF₃ N lene)phenyl I-172 H 3,4(1,3-Dioxomethy- H OMe CH CF₃ N lene)phenyl I-173 H 3,4(1,3-Dioxomethy- H OMe CH H N lene)phenyl I-174 H 3,4(1,3-Dioxomethy- H SMe CH H N lene)phenyl I-175 H 3,4(1,3-Dioxomethy- H Et CH OMe N lene)phenyl I-176 H 3,4(1,3-Dioxomethy- H Me C—(CH₂)₃— N lene)phenyl I-177 H 3,4(1,3-Dioxomethy- H OMe C—(CH₂)₃— N lene)phenyl I-178 H 3,4(1,3-Dioxomethy- H Me C—(CH₂)₂—O N lene)phenyl I-179 H 3,4(1,3-Dioxomethy- H OMe C—(CH₂)₂—O N lene)phenyl I-180 H 3,4(1,3-Dioxomethy- H OMe N OMe N lene)phenyl I-181 H 3,4(1,3-Dioxomethy- H NH₂ N NH₂ N lene)phenyl I-182 H 3,4(1,3-Dioxomethy- H NHMe N NHMe N lene)phenyl I-183 H 3,4(1,3-Dioxomethy- H OMe N OMe CH lene)phenyl I-184 H 3,4(1,3-Dioxomethy- H Cl N Me CH lene)phenyl I-185 H 3,4(1,3-Dioxomethy- H OMe N N═CH—NH—C lene)phenyl I-186 H 3,4(1,3-Dioxomethy- H Cl N N═CH—NH—C lene)phenyl I-187 H 3,4(1,3-Dioxomethy- H Me N Me CH lene)phenyl I-188 H 3,4(1,3-Dioxomethy- H OMe N Me CH lene)phenyl I-189 H 3,4(1,3-Dioxomethy- H OMe N H C—NO₂ lene)phenyl I-190 H 3,4(1,3-Dioxomethy- H OMe C—Me H N lene)phenyl I-191 H 3,4(1,3-Dioxomethy- H Me C—Me H N lene)phenyl I-192 H 3,4(1,3-Dioxomethy- Me OMe CH OMe N lene)phenyl I-193 H 3,4(1,3-Dioxomethy- Me OMe CH Me N lene)phenyl I-194 H 3,4(1,3-Dioxomethy- Me Me CH Me N lene)phenyl I-195 Cyclohexyl Cyclohexyl H OMe CH OMe N I-196 Cyclohexyl Cyclohexyl H OMe CH Me N I-197 Cyclohexyl Cyclohexyl H Me CH Me N I-198 Cyclohexyl Cyclohexyl H Me CH Et N I-199 Cyclohexyl Cyclohexyl H Et CH Et N I-200 Cyclohexyl Cyclohexyl H Me CH CF₃ N I-201 Cyclohexyl Cyclohexyl H OMe CH CF₃ N I-202 Cyclohexyl Cyclohexyl H OMe CH H N I-203 Cyclohexyl Cyclohexyl H SMe CH H N I-204 Cyclohexyl Cyclohexyl H Et CH OMe N I-205 Cyclohexyl Cyclohexyl H Me C—(CH₂)₃— N I-206 Cyclohexyl Cyclohexyl H OMe C—(CH₂)₃— N I-207 Cyclohexyl Cyclohexyl H Me C—(CH₂)₂—O N I-208 Cyclohexyl Cyclohexyl H OMe C—(CH₂)₂—O N I-209 Cyclohexyl Cyclohexyl H OMe N OMe N I-210 Cyclohexyl Cyclohexyl H NH₂ N NH₂ N I-211 Cyclohexyl Cyclohexyl H NHMe N NHMe N I-212 Cyclohexyl Cyclohexyl H OMe N OMe CH I-213 Cyclohexyl Cyclohexyl H Cl N Me CH I-214 Cyclohexyl Cyclohexyl H OMe N N=CH—NH—C I-215 Cyclohexyl Cyclohexyl H Cl N N═CH—NH—C I-216 Cyclohexyl Cyclohexyl H Me N Me CH I-217 Cyclohexyl Cyclohexyl H OMe N Me CH I-218 Cyclohexyl Cyclohexyl H OMe N H C—NO₂ I-219 Cyclohexyl Cyclohexyl H OMe C—Me H N I-220 Cyclohexyl Cyclohexyl H Me C—Me H N I-221 Cyclohexyl Cyclohexyl Me OMe CH OMe N I-222 Cyclohexyl Cyclohexyl Me OMe CH Me N I-223 Cyclohexyl Cyclohexyl Me Me CH Me N I-224 H p-Phenylphenyl H OMe CH OMe N I-225 H p-Phenylphenyl H OMe CH Me N I-226 H p-Phenylphenyl H Me CH Me N I-227 H p-Phenylphenyl H Me CH Et N I-228 H p-Phenylphenyl H Et CH Et N I-229 H p-Phenylphenyl H Me CH CF₃ N I-230 H p-Phenylphenyl H OMe CH CF₃ N I-231 H p-Phenylphenyl H OMe CH H N I-232 H p-Phenylphenyl H SMe CH H N I-233 H p-Phenylphenyl H Et CH OMe N I-234 H p-Phenylphenyl H Me C—(CH₂)₃— N I-235 H p-Phenylphenyl H OMe C—(CH₂)₃— N I-236 H p-Phenylphenyl H Me C—(CH₂)₂—O N I-237 H p-Phenylphenyl H OMe C—(CH₂)₂—O N I-238 H p-Phenylphenyl H OMe N OMe N I-239 H p-Phenylphenyl H NH₂ N NH₂ N I-240 H p-Phenylphenyl H NHMe N MHMe N I-241 H p-Phenylphenyl H OMe N OMe CH I-242 H p-Phenylphenyl H Cl N Me CH I-243 H p-Phenylphenyl H OMe N N═CH—NH—C I-244 H p-Phenylphenyl H Cl N N═CH—NH—C I-245 H p-Phenylphenyl H Me N Me CH I-246 H p-Phenylphenyl H OMe N Me CH I-247 H p-Phenylphenyl H OMe N H C—NO₂ I-248 H p-Phenylphenyl H OMe C—Me H N I-249 H p-Phenylphenyl H Me C—Me H N I-250 H p-Phenylphenyl Me OMe CH OMe N I-251 H p-Phenylphenyl Me OMe CH Me N I-252 H p-Phenylphenyl Me Me CH Me N I-253 Phenyl Phenyl H OMe CH OMe N 69 I-254 Phenyl Phenyl H OMe CH Me N I-255 Phenyl Phenyl H Me CH Me N 172-174 I-256 Phenyl Phenyl H Me CH Et N I-257 Phenyl Phenyl H Et CH Et N I-258 Phenyl Phenyl H Me CH CF₃ N I-259 Phenyl Phenyl H OMe CH CF₃ N I-260 Phenyl Phenyl H OMe CH H N I-261 Phenyl Phenyl H SMe CH H N I-262 Phenyl Phenyl H Et CH OMe N I-263 Phenyl Phenyl H CF₃ CH H N 203-208 I-264 Phenyl Phenyl H Me CH H N I-265 Phenyl Phenyl H Me C—(CH₂)₃— N I-266 Phenyl Phenyl H OMe C—(CH₂)₃— N I-267 Phenyl Phenyl H Me C—(CH₂)₂—O N I-268 Phenyl Phenyl H OMe C—(CH₂)₂—O N I-269 Phenyl Phenyl H OMe N OMe N 172-175 I-270 Phenyl Phenyl H NH₂ N NH₂ N I-271 Phenyl Phenyl H NHMe N NHMe N I-272 Phenyl Phenyl H Me N Me N I-273 Phenyl Phenyl H SMe N SMe N 68-75 I-274 Phenyl Phenyl H H CH H N I-275 Phenyl Phenyl H OMe N OMe CH I-276 Phenyl Phenyl H Cl N Me CH I-277 Phenyl Phenyl H OMe N N═CH—NH—C I-278 Phenyl Phenyl H Cl N N═CH—NH—C I-279 Phenyl Phenyl H H N N═CH—NH—C I-280 Phenyl Phenyl H SMe N H CH I-281 Phenyl Phenyl H CMe₃ N CF₃ CH 56-63 I-282 Phenyl Phenyl H OMe N Me CH I-283 Phenyl Phenyl H OMe N H C—NO₂ I-284 Phenyl Phenyl H OMe C—Me H N I-285 Phenyl Phenyl H Me C—Me H N I-286 Phenyl Phenyl H OMe CH H C—NO₂ 172-180 I-287 Phenyl Phenyl H Me CH H C—NO₂ I-288 Phenyl Phenyl H OMe CH H C—NH₂ I-289 Phenyl Phenyl H OMe C—NO₂ OMe CH I-290 Phenyl Phenyl H OMe C—NO₂ H CH I-291 Phenyl Phenyl H Me C—NO₂ Me CH I-292 Phenyl Phenyl H Me C—NH₂ Me CH I-293 Phenyl Phenyl H Me C—NO₂ OMe CH I-294 Phenyl Phenyl H Me C—NH₂ OMe CH I-295 Phenyl Phenyl Me OMe CH OMe N I-296 Phenyl Phenyl Me OMe CH Me N I-297 Phenyl Phenyl Me Me CH Me N I-298 Phenyl Phenyl Me OMe N OMe N I-299 3-Methoxyphenyl 3-Methoxyphenyl H OMe CH OMe N 58-66 I-300 3-Methoxyphenyl 3-Methoxyphenyl H OMe CH Me N I-301 3-Methoxyphenyl 3-Methoxyphenyl H Me CH Me N I-302 3-Methoxyphenyl 3-Methoxyphenyl H Me CH Et N I-303 3-Methoxyphenyl 3-Methoxyphenyl H Et CH Et N I-304 3-Methoxyphenyl 3-Methoxyphenyl H Me CH CF₃ N I-305 3-Methoxyphenyl 3-Methoxyphenyl H OMe CH CF₃ N I-306 3-Methoxyphenyl 3-Methoxyphenyl H OMe CH H N I-307 3-Methoxyphenyl 3-Methoxyphenyl H SMe CH H N I-308 3-Methoxyphenyl 3-Methoxyphenyl H Et CH OMe N I-309 3-Methoxyphenyl 3-Methoxyphenyl H Me C—(CH₂)₃— N I-310 3-Methoxyphenyl 3-Methoxyphenyl H OMe C—(CH₂)₃— N I-311 3-Methoxyphenyl 3-Methoxyphenyl H Me C—(CH₂)₂—O N I-312 3-Methoxyphenyl 3-Methoxyphenyl H OMe C—(CH₂)₂—O N I-313 3-Methoxyphenyl 3-Methoxyphenyl H OMe N OMe N I-314 3-Methoxyphenyl 3-Methoxyphenyl H NH₂ N NH₂ N I-315 3-Methoxyphenyl 3-Methoxyphenyl H NHMe N NHMe N I-316 3-Methoxyphenyl 3-Methoxyphenyl H OMe N OMe CH I-317 3-Methoxyphenyl 3-Methoxyphenyl H Cl N Me CH I-318 3-Methoxyphenyl 3-Methoxyphenyl H OMe N N═CH—NH—C I-319 3-Methoxyphenyl 3-Methoxyphenyl H Cl N N═CH—NH—C I-320 3-Methoxyphenyl 3-Methoxyphenyl H Me N Me CH I-321 3-Methoxyphenyl 3-Methoxyphenyl H OMe N Me CH I-322 3-Methoxyphenyl 3-Methoxyphenyl H OMe N H C—NO₂ I-323 3-Methoxyphenyl 3-Methoxyphenyl H OMe C—Me H N I-324 3-Methoxyphenyl 3-Methoxyphenyl H Me C—Me H N I-325 3-Methoxyphenyl 3-Methoxyphenyl Me OMe CH OMe N I-326 3-Methoxyphenyl 3-Methoxyphenyl Me OMe CH Me N I-327 3-Methoxyphenyl 3-Methoxyphenyl Me Me CH Me N I-328

H OMe N OMe N 182-186 I-329

H OMe CH OMe N I-330

H Me CH Me N I-331

H Me CH OMe N I-332

H OMe C—Me H N I-333

H OMe CH H N I-334

H OMe N OMe CH

TABLE 2 I

No. R⁴ R⁵ R⁷ R² X R³ Y M.p. [° C.] I-335 Phenyl Phenyl H OMe CH OMe N I-336 Phenyl Phenyl H OMe CH Me N I-337 Phenyl Phenyl H Me CH Me N I-338 Phenyl Phenyl H Me CH Et N I-339 Phenyl Phenyl H Et CH Et N I-340 Phenyl Phenyl H Me CH CF₃ N I-341 Phenyl Phenyl H OMe CH CF₃ N I-342 Phenyl Phenyl H OMe CH H N I-343 Phenyl Phenyl H SMe CH H N I-344 Phenyl Phenyl H Et CH OMe N I-345 Phenyl Phenyl H CF₃ CH H N I-346 Phenyl Phenyl H Me CH H N I-347 Phenyl Phenyl H Me C—(CH₂)₃— N I-348 Phenyl Phenyl Me OMe C—(CH₂)₃— CH I-349 Phenyl Phenyl Me Me C—(CH₂)₂—O N I-350 Phenyl Phenyl Me OMe C—(CH₂)₂—O N I-351 Phenyl Phenyl H OMe N OMe N I-352 Phenyl Phenyl H NH₂ N NH₂ N I-353 Phenyl Phenyl H NHMe N NHMe N I-354 Phenyl Phenyl H Me N Me N I-355 Phenyl Phenyl H SMe N SMe N I-356 Phenyl Phenyl H H CH H N I-357 Phenyl Phenyl H OMe N OMe CH I-358 Phenyl Phenyl H Cl N Me CH I-359 Phenyl Phenyl H OMe N N═CH—NH—C I-360 Phenyl Phenyl H Cl N N═CH—NH—C I-361 Phenyl Phenyl H H N N═CH—NH—C I-362 Phenyl Phenyl H SMe N H CH I-363 Phenyl Phenyl H CMe₃ N CF₃ CH I-364 Phenyl Phenyl H OMe N Me CH I-365 Phenyl Phenyl H OMe N H C—NO₂ I-366 Phenyl Phenyl H OMe C—Me H N I-367 Phenyl Phenyl H Me C—Me H N I-368 Phenyl Phenyl H OMe CH H C—NO₂ I-369 Phenyl Phenyl H Me CH H C—NO₂ I-370 Phenyl Phenyl H OMe CH H C—NH₂ I-371 Phenyl Phenyl H OMe C—NO₂ OMe CH I-372 Phenyl Phenyl H OMe C—NO₂ H CH I-373 Phenyl Phenyl H Me C—NO₂ Me CH I-374 Phenyl Phenyl H Me C—NH₂ Me CH I-375 Phenyl Phenyl H Me C—NO₂ OMe CH I-376 Phenyl Phenyl H Me C—NH₂ OMe CH I-377 Phenyl Phenyl Me OMe CH OMe N I-378 Phenyl Phenyl Me OMe CH Me N I-379 Phenyl Phenyl Me Me CH Me N I-380 Phenyl Phenyl Me OMe N OMe N I-381 Me Phenyl H OMe CH OMe N I-382 Me Phenyl H OMe CH Me N I-383 Me Phenyl H Me CH Me N I-384 Me Phenyl H Me CH Et N I-385 Me Phenyl H Et CH Et N I-386 Me Phenyl H Me CH CF₃ N I-387 Me Phenyl H OMe CH CF₃ N I-388 Me Phenyl H OMe CH H N I-389 Me Phenyl H SMe CH H N I-390 Me Phenyl H Et CH OMe N I-391 Me Phenyl H CF₃ CH H N I-392 Me Phenyl H Me CH H N I-393 Me Phenyl H Me C—(CH₂)₃— N I-394 Me Phenyl H OMe C—(CH₂)₃— N I-395 Me Phenyl H Me C—(CH₂)₂—O N I-396 Me Phenyl H OMe C—(CH₂)₂—O N I-397 Me Phenyl H OMe N OMe N I-398 Me Phenyl H NH₂ N NH₂ N I-399 Me Phenyl H NHMe N NHMe N I-400 Me Phenyl H Me N Me N I-401 Me Phenyl H SMe N SMe N I-402 Me Phenyl H H CH H N I-403 Me Phenyl H OMe N OMe CH I-404 Me Phenyl H Cl N Me CH I-405 Me Phenyl H OMe N N═CH—NH—C I-406 Me Phenyl H Cl N N═CH—NH—C I-407 Me Phenyl H H N N═CH—NH—C I-408 Me Phenyl H SMe N H CH I-409 Me Phenyl H CMe₃ N CF₃ CH I-410 Me Phenyl H OMe N Me CH I-411 Me Phenyl H OMe N H C—NO₂ I-412 Me Phenyl H OMe C—Me H N I-413 Me Phenyl H Me C—Me H N I-414 Me Phenyl H OMe CH H C—NO₂ I-415 Me Phenyl H Me CH H C—NO₂ I-416 Me Phenyl H OMe CH H C—NH₂ I-417 Me Phenyl H OMe C—NO₂ OMe CH I-418 Me Phenyl H OMe C—NO₂ H CH I-419 Me Phenyl H Me C—NO₂ Me CH I-420 Me Phenyl H Me C—NH₂ Me CH I-421 Me Phenyl H Me C—NO₂ OMe CH I-422 Me Phenyl H Me C—NH₂ OMe CH I-423 Me Phenyl Me OMe CH OMe N I-424 Me Phenyl Me OMe CH Me N I-425 Me Phenyl Me Me CH Me N I-426 Me Phenyl Me OMe N OMe N I-427 Me 3,4(1,3-Dioxomethy- H OMe CH OMe N lene)phenyl I-428 Me 3,4(1,3-Dioxomethy- H OMe CH Me N lene)phenyl I-429 Me 3,4(1,3-Dioxomethy- H Me CH Me N lene)phenyl I-430 Me 3,4(1,3-Dioxomethy- H Me CH Et N lene)phenyl I-431 Me 3,4(1,3-Dioxomethy- H Et CH Et N lene)phenyl I-432 Me 3,4(1,3-Dioxomethy- H Me CH CF₃ N lene)phenyl I-433 Me 3,4(1,3-Dioxomethy- H OMe CH CF₃ N lene)phenyl I-434 Me 3,4(1,3-Dioxomethy- H OMe CH H N lene)phenyl I-435 Me 3,4(1,3-Dioxomethy- H SMe CH H N lene)phenyl I-436 Me 3,4(1,3-Dioxomethy- H Et CH OMe N lene)phenyl I-437 Me 3,4(1,3-Dioxomethy- H CF₃ CH H N lene)phenyl I-438 Me 3,4(1,3-Dioxomethy- H Me CH H N lene)phenyl I-439 Me 3,4(1,3-Dioxomethy- H Me C—(CH₂)₃— N lene)phenyl I-440 Me 3,4(1,3-Dioxomethy- H OMe C—(CH₂)₃— N lene)phenyl I-441 Me 3,4(1,3-Dioxomethy- H Me C—(CH₂)₂—O N lene)phenyl I-442 Me 3,4(1,3-Dioxomethy- H OMe C—(CH₂)₂—O N lene)phenyl I-443 Me 3,4(1,3-Dioxomethy- H OMe N OMe N lene)phenyl I-444 Me 3,4(1,3-Dioxomethy- H NH₂ N NH₂ N lene)phenyl I-445 Me 3,4(1,3-Dioxomethy- H NHMe N NHMe N lene)phenyl I-446 Me 3,4(1,3-Dioxomethy- H Me N Me N lene)phenyl I-447 Me 3,4(1,3-Dioxomethy- H SMe N SMe N lene)phenyl I-448 Me 3,4(1,3-Dioxomethy- H H CH H N lene)phenyl I-449 Me 3,4(1,3-Dioxomethy- H OMe N OMe CH lene)phenyl I-450 Me 3,4(1,3-Dioxomethy- H Cl N Me CH lene)phenyl I-451 Me 3,4(1,3-Dioxomethy- H OMe N N═CH—NH—C lene)phenyl I-452 Me 3,4(1,3-Dioxomethy- H Cl N N═CH—NH—C lene)phenyl I-453 Me 3,4(1,3-Dioxomethy- H H N N═CH—NH—C lene)phenyl I-454 Me 3,4(1,3-Dioxomethy- H SMe N H CH lene)phenyl I-455 Me 3,4(1,3-Dioxomethy- H CMe₃ N CF₃ CH lene)phenyl I-456 Me 3,4(1,3-Dioxomethy- H OMe N Me CH lene)phenyl I-457 Me 3,4(1,3-Dioxomethy- H OMe N H C—NO₂ lene)phenyl I-458 Me 3,4(1,3-Dioxomethy- H OMe C—Me H N lene)phenyl I-459 Me 3,4(1,3-Dioxomethy- H Me C—Me H N lene)phenyl I-460 Me 3,4(1,3-Dioxomethy- H OMe CH H C—NO₂ lene)phenyl I-461 Me 3,4(1,3-Dioxomethy- H Me CH H C—NO₂ lene)phenyl I-462 Me 3,4(1,3-Dioxomethy- H OMe CH H C—NH₂ lene)phenyl I-463 Me 3,4(1,3-Dioxomethy- H OMe C—NO₂ OMe CH lene)phenyl I-464 Me 3,4(1,3-Dioxomethy- H OMe C—NO₂ H CH lene)phenyl I-465 Me 3,4(1,3-Dioxomethy- H Me C—NO₂ Me CH lene)phenyl I-466 Me 3,4(1,3-Dioxomethy- H Me C—NH₂ Me CH lene)phenyl I-467 Me 3,4(1,3-Dioxomethy- H Me C—NO₂ OMe CH lene)phenyl I-468 Me 3,4(1,3-Dioxomethy- H Me C—NH₂ OMe CH lene)phenyl I-469 Me 3,4(1,3-Dioxomethy- Me OMe CH OMe N lene)phenyl I-470 Me 3,4(1,3-Dioxomethy- Me OMe CH Me N lene) phenyl I-471 Me 3,4(1,3-Dioxomethy- Me Me CH Me N lene)phenyl I-472 Me 3,4(1,3-Dioxomethy- Me OMe N OMe N lene)phenyl I-473 Me 3,4-Dimethoxyphenyl H OMe N OMe N I-474 Me 3,4-Dimethoxyphenyl H OMe CH OMe N I-475 Me 3,4-Dimethoxyphenyl H Me CH OMe N I-476 Me 3,4-Dimethoxyphenyl H Me CH Me N I-477 Me 3,4-Dimethoxyphenyl H OMe N OMe CH I-478 Me 3,4-Dimethoxyphenyl Me OMe CH OMe N I-479 Me 3,4-Dimethoxyphenyl Me OMe N OMe N I-480 Me 3,4-Dimethoxyphenyl H OMe CH H N I-481 Me 3,4-Dimethoxyphenyl H OMe C—Me H N I-482 Me 4-Methoxyphenyl H OMe CH OMe N I-483 Me 4-Methoxyphenyl H Me CH OMe N I-484 Me 4-Methoxyphenyl H Me CH Me N I-485 Me 4-Methoxyphenyl H OMe N OMe CH I-486 Me 4-Methoxyphenyl H OMe CH H N I-487 Me 4-Methoxyphenyl H OMe C—Me H N I-488 Me 4-Methoxyphenyl H OMe N OMe N I-489 Me 4-Methoxyphenyl Me OMe CH OMe N I-490 Me 4-Methoxyphenyl Me OMe N OMe N I-491 Me 3-Methoxyphenyl H OMe CH OMe N I-492 Me 3-Methoxyphenyl H Me CH OMe N I-493 Me 3-Methoxyphenyl H Me CH Me N I-494 Me 3-Methoxyphenyl H OMe N OMe CH I-495 Me 3-Methoxyphenyl H OMe CH H N I-496 Me 3-Methoxyphenyl H OMe C—Me H N I-497 Me 3-Methoxyphenyl H OMe N OMe N I-498 Me 3-Methoxyphenyl Me OMe CH OMe N I-499 Me 3-Methoxyphenyl Me OMe N OMe N I-500 4-Methoxyphenyl 4-Methoxyphenyl H OMe CH OMe N I-501 4-Methoxyphenyl 4-Methoxyphenyl H OMe CH Me N I-502 4-Methoxyphenyl 4-Methoxyphenyl H Me CH Me N I-503 4-Methoxyphenyl 4-Methoxyphenyl H Me CH Et N I-504 4-Methoxyphenyl 4-Methoxyphenyl H Et CH Et N I-505 4-Methoxyphenyl 4-Methoxyphenyl H Me CH CF₃ N I-506 4-Methoxyphenyl 4-Methoxyphenyl H OMe CH CF₃ N I-507 4-Methoxyphenyl 4-Methoxyphenyl H OMe CH H N I-508 4-Methoxyphenyl 4-Methoxyphenyl H SMe CH H N I-509 4-Methoxyphenyl 4-Methoxyphenyl H Et CH OMe N I-510 4-Methoxyphenyl 4-Methoxyphenyl H CF₃ CH H N I-511 4-Methoxyphenyl 4-Methoxyphenyl H Me CH H N I-512 4-Methoxyphenyl 4-Methoxyphenyl H Me C—(CH₂)₃— N I-513 4-Methoxyphenyl 4-Methoxyphenyl H OMe C—(CH₂)₃— N I-514 4-Methoxyphenyl 4-Methoxyphenyl H Me C—(CH₂)₂—O N I-515 4-Methoxyphenyl 4-Methoxyphenyl H OMe C—(CH₂)₂—O N I-516 4-Methoxyphenyl 4-Methoxyphenyl H OMe N OMe N I-517 4-Methoxyphenyl 4-Methoxyphenyl H NH₂ N NH₂ N I-518 4-Methoxyphenyl 4-Methoxyphenyl H NHMe N NHMe N I-519 4-Methoxyphenyl 4-Methoxyphenyl H Me N Me N I-520 4-Methoxyphenyl 4-Methoxyphenyl H SMe N SMe N I-521 4-Methoxyphenyl 4-Methoxyphenyl H H CH H N I-522 4-Methoxyphenyl 4-Methoxyphenyl H OMe N OMe CH I-523 4-Methoxyphenyl 4-Methoxyphenyl H Cl N Me CH I-524 4-Methoxyphenyl 4-Methoxyphenyl H OMe N N═CH—NH—C I-525 4-Methoxyphenyl 4-Methoxyphenyl H Cl N N═CH—NH—C I-526 4-Methoxyphenyl 4-Methoxyphenyl H H N N═CH—NH—C I-527 4-Methoxyphenyl 4-Methoxyphenyl H SMe N H CH I-528 4-Methoxyphenyl 4-Methoxyphenyl H CMe₃ N CF₃ CH I-529 4-Methoxyphenyl 4-Methoxyphenyl H OMe N Me CH I-530 4-Methoxyphenyl 4-Methoxyphenyl H OMe N H C—NO₂ I-531 4-Methoxyphenyl 4-Methoxyphenyl H OMe C—Me H N I-532 4-Methoxyphenyl 4-Methoxyphenyl H Me C—Me H N I-533 4-Methoxyphenyl 4-Methoxyphenyl H OMe CH H C—NO₂ I-534 4-Methoxyphenyl 4-Methoxyphenyl H Me CH H C—NO₂ I-535 4-Methoxyphenyl 4-Methoxyphenyl H OMe CH H C—NH₂ I-536 4-Methoxyphenyl 4-Methoxyphenyl H OMe C—NO₂ OMe CH I-537 4-Methoxyphenyl 4-Methoxyphenyl H OMe C—NO₂ H CH I-538 4-Methoxyphenyl 4-Methoxyphenyl H Me C—NO₂ Me CH I-539 4-Methoxyphenyl 4-Methoxyphenyl H Me C—NH₂ Me CH I-540 4-Methoxyphenyl 4-Methoxyphenyl H Me C—NO₂ OMe CH I-541 4-Methoxyphenyl 4-Methoxyphenyl H Me C—NH₂ OMe CH I-542 4-Methoxyphenyl 4-Methoxyphenyl Me OMe CH OMe N I-543 4-Methoxyphenyl 4-Methoxyphenyl Me OMe CH Me N I-544 4-Methoxyphenyl 4-Methoxyphenyl Me Me CH Me N I-545 4-Methoxyphenyl 4-Methoxyphenyl Me OMe N OMe N

TABLE 3 I

No. R⁴ R⁵ R⁷ R² X R³ Y M.p. [° C.] I-546 Phenyl Phenyl H OMe CH OMe N I-547 Phenyl Phenyl H OMe CH Me N I-548 Phenyl Phenyl H3 Me CH Me N I-549 Phenyl Phenyl H Me CH Et N I-550 Phenyl Phenyl H Et CH Et N I-551 Phenyl Phenyl H Me CH CF₃ N I-552 Phenyl Phenyl H OMe CH CF₃ N I-553 Phenyl Phenyl H OMe CH H N I-554 Phenyl Phenyl H SMe CH H N I-555 Phenyl Phenyl H Et CH OMe N I-556 Phenyl Phenyl H CF₃ CH H N I-557 Phenyl Phenyl H Me CH H N I-558 Phenyl Phenyl H Me C—(CH₂)₃— N I-559 Phenyl Phenyl Me OMe C—(CH₂)₃— CH I-560 Phenyl Phenyl Me Me C—(CH₂)₂—O N I-561 Phenyl Phenyl Me OMe C—(CH₂)₂—O N I-562 Phenyl Phenyl H OMe N OMe N I-563 Phenyl Phenyl H NH₂ N NH₂ N I-564 Phenyl Phenyl H NHMe N NHMe N I-565 Phenyl Phenyl H Me N Me N I-566 Phenyl Phenyl H SMe N SMe N I-567 Phenyl Phenyl H H CH H N I-568 Phenyl Phenyl H OMe N OMe CH I-569 Phenyl Phenyl H Cl N Me CH I-570 Phenyl Phenyl H OMe N N═CH—NH—C I-571 Phenyl Phenyl H Cl N N═CH—NH—C I-572 Phenyl Phenyl H H N N═CH—NH—C I-573 Phenyl Phenyl H SMe N H CH I-574 Phenyl Phenyl H CMe₃ N CF₃ CH I-575 Phenyl Phenyl H OMe N Me CH I-576 Phenyl Phenyl H OMe N H C—NO₂ I-577 Phenyl Phenyl H OMe C—Me H N I-578 Phenyl Phenyl H Me C—Me H N I-579 Phenyl Phenyl H OMe CH H C—NO₂ I-580 Phenyl Phenyl H Me CH H C—NO₂ I-581 Phenyl Phenyl H OMe CH H C—NH₂ I-582 Phenyl Phenyl H OMe C—NO₂ OMe CH I-583 Phenyl Phenyl H OMe C—NO₂ H CH I-584 Phenyl Phenyl H Me C—NO₂ Me CH I-585 Phenyl Phenyl H Me C—NH₂ Me CH I-586 Phenyl Phenyl H Me C—NO₂ OMe CH I-587 Phenyl Phenyl H Me C—NH₂ OMe CH I-588 Phenyl Phenyl Me OMe CH OMe N I-589 Phenyl Phenyl Me OMe CH Me N I-590 Phenyl Phenyl Me Me CH Me N I-591 Phenyl Phenyl Me OMe N OMe N I-592 4-Methoxyphenyl 4-Methoxyphenyl H OMe CH OMe N I-593 4-Methoxyphenyl 4-Methoxyphenyl H OMe CH Me N I-594 4-Methoxyphenyl 4-Methoxyphenyl H Me CH Me N I-595 4-Methoxyphenyl 4-Methoxyphenyl H Me CH Et N I-596 4-Methoxyphenyl 4-Methoxyphenyl H Et CH Et N I-597 4-Methoxyphenyl 4-Methoxyphenyl H Me CH CF₃ N I-598 4-Methoxyphenyl 4-Methoxyphenyl H OMe CH CF₃ N I-599 4-Methoxyphenyl 4-Methoxyphenyl H OMe CH H N I-600 4-Methoxyphenyl 4-Methoxyphenyl H SMe CH H N I-601 4-Methoxyphenyl 4-Methoxyphenyl H Et CH OMe N I-602 4-Methoxyphenyl 4-Methoxyphenyl H CF₃ CH H N I-603 4-Methoxyphenyl 4-Methoxyphenyl H Me CH H N I-604 4-Methoxyphenyl 4-Methoxyphenyl H Me C—(CH₂)₃— N I-605 4-Methoxyphenyl 4-Methoxyphenyl H OMe C—(CH₂)₃— N I-606 4-Methoxyphenyl 4-Methoxyphenyl H Me C—(CH₂)₂—O N I-607 4-Methoxyphenyl 4-Methoxyphenyl H OMe C—(CH₂)₂—O N I-608 4-Methoxyphenyl 4-Methoxyphenyl H OMe N OMe N I-609 4-Methoxyphenyl 4-Methoxyphenyl H NH₂ N NH₂ N I-610 4-Methoxyphenyl 4-Methoxyphenyl H NHMe N NHMe N I-611 4-Methoxyphenyl 4-Methoxyphenyl H Me N Me N I-612 4-Methoxyphenyl 4-Methoxyphenyl H SMe N SMe N I-613 4-Methoxyphenyl 4-Methoxyphenyl H H CH H N I-614 4-Methoxyphenyl 4-Methoxyphenyl H OMe N OMe CH I-615 4-Methoxyphenyl 4-Methoxyphenyl H Cl N Me CH I-616 4-Methoxyphenyl 4-Methoxyphenyl H OMe N N═CH—NH—C I-617 4-Methoxyphenyl 4-Methoxyphenyl H Cl N N═CH—NH—C I-618 4-Methoxyphenyl 4-Methoxyphenyl H H N N═CH—NH—C I-619 4-Methoxyphenyl 4-Methoxyphenyl H SMe N H CH I-620 4-Methoxyphenyl 4-Methoxyphenyl H CMe₃ N CF₃ CH I-621 4-Methoxyphenyl 4-Methoxyphenyl H OMe N Me CH I-622 4-Methoxyphenyl 4-Methoxyphenyl H OMe N H C—NO₂ I-623 4-Methoxyphenyl 4-Methoxyphenyl H OMe C—Me H N I-624 4-Methoxyphenyl 4-Methoxyphenyl H Me C—Me H N I-625 4-Methoxyphenyl 4-Methoxyphenyl H OMe CH H C—NO₂ I-626 4-Methoxyphenyl 4-Methoxyphenyl H Me CH H C—NO₂ I-627 4-Methoxyphenyl 4-Methoxyphenyl H OMe CH H C—NH₂ I-628 4-Methoxyphenyl 4-Methoxyphenyl H OMe C—NO₂ OMe CH I-629 4-Methoxyphenyl 4-Methoxyphenyl H OMe C—NO₂ H CH I-630 4-Methoxyphenyl 4-Methoxyphenyl H Me C—NO₂ Me CH I-631 4-Methoxyphenyl 4-Methoxyphenyl H Me C—NH₂ Me CH I-632 4-Methoxyphenyl 4-Methoxyphenyl H Me C—NO₂ OMe CH I-633 4-Methoxyphenyl 4-Methoxyphenyl H Me C—NH₂ OMe CH I-634 4-Methoxyphenyl 4-Methoxyphenyl Me OMe CH OMe N I-635 4-Methoxyphenyl 4-Methoxyphenyl Me OMe CH Me N I-636 4-Methoxyphenyl 4-Methoxyphenyl Me Me CH Me N I-637 4-Methoxyphenyl 4-Methoxyphenyl Me OMe N OMe N I-638 Et Phenyl H OMe CH OMe N I-639 Et Phenyl H Me CH OMe N I-640 Et Phenyl H Me CH Me N I-641 Et Phenyl H OMe CH OMe CH I-642 Et Phenyl H OMe C—Me H N I-643 Et Phenyl H OMe N H N I-644 Et Phenyl H OMe CH OMe N I-645 Et Phenyl Me OMe N OMe N I-646 Et Phenyl Me Me CH OMe N I-647 Et Phenyl Me Me CH Me N

TABLE 4 I

No. R⁴ R⁵ R⁷ R² X R³ Y M.p. [° C.] I-648 Phenyl Phenyl H OMe CH OMe N I-649 Phenyl Phenyl H OMe CH Me N I-650 Phenyl Phenyl H Me CH Me N I-651 Phenyl Phenyl H Me CH Et N I-652 Phenyl Phenyl H Et CH Et N I-653 Phenyl Phenyl H Me CH CF₃ N I-654 Phenyl Phenyl H OMe CH CF₃ N I-655 Phenyl Phenyl H OMe CH H N I-656 Phenyl Phenyl H SMe CH H N I-657 Phenyl Phenyl H Et CH OMe N I-658 Phenyl Phenyl H CF₃ CH H N I-659 Phenyl Phenyl H Me CH H N I-660 Phenyl Phenyl H Me C—(CH₂)₃— N I-661 Phenyl Phenyl Me OMe C—(CH₂)₃— CH I-662 Phenyl Phenyl Me Me C—(CH₂)₂—O N I-663 Phenyl Phenyl Me OMe C—(CH₂)₂—O N I-664 Phenyl Phenyl H OMe N OMe N I-665 Phenyl Phenyl H NH₂ N NH₂ N I-666 Phenyl Phenyl H NHMe N NHMe N I-667 Phenyl Phenyl H Me N Me N I-668 Phenyl Phenyl H SMe N SMe N I-669 Phenyl Phenyl H H CH H CH I-670 Phenyl Phenyl H OMe N OMe CH I-671 Phenyl Phenyl H Cl N Me CH I-672 Phenyl Phenyl H OMe N N═CH—NH—C I-673 Phenyl Phenyl H Cl N N═CH—NH—C I-674 Phenyl Phenyl H H N N═CH—NH—C I-675 Phenyl Phenyl H SMe N H CH I-676 Phenyl Phenyl H CMe₃ N CF₃ CH I-677 Phenyl Phenyl H OMe N Me CH I-678 Phenyl Phenyl H OMe N H C—NO₂ I-679 Phenyl Phenyl H OMe C—Me H N I-680 Phenyl Phenyl H Me C—Me H N I-681 Phenyl Phenyl H OMe CH H C—NO₂ I-682 Phenyl Phenyl H Me CH H C—NO₂ I-683 Phenyl Phenyl H OMe CH H C—NH₂ I-684 Phenyl Phenyl H OMe C—NO₂ OMe CH I-685 Phenyl Phenyl H OMe C—NO₂ H CH I-686 Phenyl Phenyl H Me C—NO₂ Me CH I-687 Phenyl Phenyl H Me C—NH₂ Me CH I-688 Phenyl Phenyl H Me C—NO₂ OMe CH I-689 Phenyl Phenyl H Me C—NH₂ OMe CH I-690 Phenyl Phenyl Me OMe CH OMe N I-691 Phenyl Phenyl Me OMe CH Me N I-692 Phenyl Phenyl Me Me CH Me N I-693 Phenyl Phenyl Me OMe N OMe N I-694 Me Phenyl H OMe CH OMe N I-695 Me Phenyl H OMe CH Me N I-696 Me Phenyl H Me CH Me CH I-697 Me Phenyl H OMe N OMe CH I-698 Me Phenyl H OMe CH H N I-699 Me Phenyl H OMe C—Me H N I-700 Me Phenyl H OMe N OMe N I-701 Me Phenyl Me OMe CH OMe N I-702 Me Phenyl Me OMe N OMe N I-703 Me Phenyl Me Me CH Me N I-704 H Phenyl H OMe CH OMe N I-705 H Phenyl H OMe CH Me N I-706 H Phenyl H Me CH Me N I-707 H Phenyl H OMe N OMe CH I-708 H Phenyl H OMe CH H N I-709 H Phenyl H OMe C—Me H N I-710 H Phenyl H OMe N OMe N I-711 H Phenyl Me OMe CH OMe N I-712 H Phenyl Me OMe N OMe N I-713 H Phenyl Me Me CH Me N

TABLE 5

I No. Structure M.p. [° C.] I-714

I-715

I-716

I-717

I-718

I-719

I-720

I-721

I-722

I-723

I-724

I-725

I-726

I-727

I-728

I-729

I-730

I-731

I-732

I-733

I-734

I-735

I-736

I-737

I-738

I-739

I-740

I-741

I-742

I-743

I-744

I-745

I-746

I-747

I-748

I-749

I-750

I-751

I-752

I-753 

We claim:
 1. A compound of formula I

where R is tetrazolyl, cyano or a radical

where R¹ has the following meanings: b) succinimidyl; d) a radical

 where k is 0, 1 or 2, p is 1, 2, 3 or 4, and R⁹ is C₁-C₄-alkyl, C₃-C₇-cycloalkyl, C₃-C₆-alkenyl, C₃-C₆-alkynyl or phenyl which is unsubstituted or substituted by one or more of the following radicals: halogen, nitro, cyano, C₁-C₄-alkyl, C₁-C₄-haloalkyl, hydroxyl, C₁-C₄-alkoxy, C₁-C₄-alkylthio, mercapto, amino, C₁-C₄-alkylamino and C₁-C₄-dialkylamino; e) a radical OR¹⁰, where R¹⁰ is: hydrogen, an alkali metal cation or an alkaline earth metal cation, ammonium or a physiologically tolerated alkylammonium ion, C₃-C₈-cycloalkyl; C₁-C₈-alkyl; benzyl which is unsubstituted or substituted by one or more of the following radicals: halogen, nitro, cyano, C₁-C₄-alkyl, C₁-C₄-haloalkyl, hydroxyl, C₁-C₄-alkoxy, mercapto, C₁-C₄-alkylthio, amino, C₁-C₄-alkylamino and C₁-C₄-dialkylamino; C₃-C₆-alkenyl or C₃-C₆-alkynyl, which is unsubstituted or carries one to five halogen atoms; phenyl which is unsubstituted or substituted by one to five halogen atoms and/or from one to three of the following radicals: nitro, cyano, C₁-C₄-alkyl, C₁-C₄-haloalkyl, hydroxyl, C₁-C₄-alkoxy, mercapto, C₁-C₄-alkylthio, amino, C₁-C₄-alkylamino and C₁-C₄-dialkylamino; f) a radical

 where R¹¹ is: C₁-C₄-alkyl, C₃-C₆-alkenyl, C₃-C₆-alkynyl, C₃-C₈-cycloalkyl, which radicals are unsubstituted or carry a C₁-C₄-alkoxy, C₁-C₄-alkylthio and/or phenyl radical; phenyl which is unsubstituted or substituted by one to five halogen atoms and/or one to three of the following radicals: nitro, cyano, C₁-C₄-alkyl, C₁-C₄-haloalkyl, hydroxyl, C₁-C₄-alkoxy, mercapto, C₁-C₄-alkylthio, amino, C₁-C₄-alkylamino and C₁-C₄-dialkylamino; g) a radical

 where R¹² is C₁-C₄-alkyl, C₃-C₆-alkenyl, C₃-C₆-alkynyl, C₃-C₈-cycloalkyl, which radicals are unsubstituted or carry a C₁-C₄-alkoxy, C₁-C₄-alkylthio and/or phenyl radical; phenyl which is unsubstituted or substituted by one to five halogen atoms and/or one to three of the following radicals: nitro, cyano, C₁-C₄-alkyl, C₁-C₄-haloalkyl, hydroxyl, C₁-C₄-alkoxy, mercapto, C₁-C₄-alkylthio, amino, C₁-C₄-alkylamino and C₁-C₄-dialkylamino; h) a radical

 where R¹³ and R¹⁴, independently of one another, are hydrogen, C₁-C₇-alkyl, C₃-C₇-cycloalkyl, C₃-C₇-alkenyl, C₃-C₇-alkynyl, benzyl or phenyl which are unsubstituted or substituted by one to five halogen atoms and/or one to three of the following radicals: nitro, cyano, C₁-C₄-alkyl, C₁-C₄-haloalkyl, hydroxyl, C₁-C₄-alkoxy, mercapto, C₁-C₄-alkylthio, amino, C₁-C₄-alkylamino and C₁-C₄-dialkylamino; or R¹³ and R¹⁴ together form a C₄-C₇-alkylene chain or a chain consisting of 4 to 7 methylene members and one member selected from the group of oxygen, nitrogen and sulfur, which chain is unsubstituted or substituted by C₁-C₄-alkyl; tetrazole or nitrile; and W is nitrogen; R² is hydrogen, halogen, C₁-C₄-alkyl, C₁-C₄-haloalkyl, C₁-C₄-alkoxy, C₁-C₄-haloalkoxy, hydroxyl, mercapto, C₁-C₄-alkylthio, nitro, amino, C₁-C₄-alkylamino or C₁-C₄-dialkylamino, cyano, phenyl which is unsubstituted or carries one to three of the following: halogen, hydroxyl, amino, mono-(C₁-C₃)-amino, dialkyl-(C₁-C₃)-amino, C₁-C₃-alkyl, C₁-C₃-alkoxy, mercapto and C₁-C₃-alkylthio; or X is CR¹⁵ where R¹⁵ is hydrogen or C₁-C₅-alkyl, C₁-C₅-alkoxy, C₁-C₅-alkylthio, nitro, phenyl, hydroxyl, mercapto, halogen, amino, C₁-C₄-alkylamino, C₁-C₄-dialkylamino or cyano, or R¹⁵ and R² to form a 5- to 6-membered alkylene or alkylidene ring or a 5- or 6-membered alkylene or alkenylene ring wherein one or two carbon ring members are replaced by a nitrogen, sulfur or oxygen atom, and which ring is unsubstituted or carries one to three of the following radicals: halogen, nitro, cyano, hydroxyl, mercapto, C₁-C₃-alkyl, C₁-C₃-haloalkyl, C₁-C₃-alkoxy, C₁-C₃-alkylthio, amino, C₁-C₃-alkylamino and C₁-C₃-dialkylamino; or R¹⁵ and R³ together with the adjacent carbon atom form a 5- or 6-membered alkylene or alkylidene ring or a 5- or 6-membered alkylene or alkenylene ring wherein one or two carbon ring members are replaced by a nitrogen, sulfur or oxygen atom, and which ring is unsubstituted or carries one to three of the following radicals: halogen, nitro, cyano, hydroxyl, mercapto, C₁-C₃-alkyl, C₁-C₃-haloalkyl, C₁-C₃-alkoxy, C₁-C₃-alkylthio, amino, C₁-C₃-alkylamino and C₁-C₃-dialkylamino; R³ is one of the radicals given for R², Y is nitrogen; R⁴ is phenyl which is unsubstituted or carries one or more of the following radicals halogen, nitro, cyano, hydroxyl, C₁-C₄-alkyl, C₁-C₄-haloalkyl, C₁-C₄-alkoxy, C₁-C₄-haloalkoxy, phenoxy, phenyl, C₁-C₄-alkylthio, amino, C₁-C₄-alkylamino and C₁-C₄-dialkylamino, or R⁴ and R⁵ are each phenyl groups which are connected to each other in the ortho positions by a direct linkage, a methylene, ethylene or ethenylene group, an oxygen or sulfur atom or an SO₂, NH or N-alkyl group; R⁵ is cyclohexyl, phenyl or naphthyl which is unsubstituted or carries from one to three of the following radicals: halogen, nitro, cyano, hydroxyl, C₁-C₄-alkyl, C₁-C₄-haloalkyl, C₁-C₄-alkoxy, C₁-C₄-haloalkoxy, phenoxy, phenyl, C₁-C₄-alkylthio, amino, C₁-C₄-alkylamino, C₁-C₄-dialkylamino and two radicals on adjacent carbon atoms which form an alkylene or alkylidene group, a ring having 5 or 6 ring members selected from methylene, methylidene and oxygen; R⁶ is hydrogen, C₁-C₄-alkyl or C₁-C₄-haloalkyl Z is a single bond, oxygen, sulfur, sulfinyl or sulfonyl; R⁷ is hydrogen or C₁-C₄-alkyl, C₂-C₄-alkenyl, C₂-C₄-alkynyl; Q is a single bond, a

 group R⁸ is hydrogen, C₁-C₄-alkyl, C₂-C₄-alkenyl, phenyl or benzyl, and R⁸ can furthermore be directly connected to R⁵ as described above, in which case R⁸ is a CH—R¹⁷ group where R¹⁷ is hydrogen, C₁-C₄-alkyl, phenyl or phenyl which is mono- to trisubstituted by methoxy, or is one of the following radicals


2. A method of treating hypertension in a patient in need of such treatment, which comprises administering an effective amount of the compound I defined in claim 1 to said patient.
 3. The method defined in claim 2, wherein the amount of the compound I is adapted to be effective to antagonize endothelin.
 4. A pharmaceutical composition comprising an effective amount of the compound I defined in claim 1 and at least one conventional pharmaceutical aid.
 5. The compound I defined in claim 1 wherein R² is hydrogen, halogen, C₁-C₄-alkyl, C₁-C₄-haloalkyl, nitro, C₁-C₄-alkoxy, C₁-C₄-alkylthio, cyano, amino, methylamino, hydroxyl or dimethylamino.
 6. The compound I defined in claim 1 wherein X is CR¹⁵ and R¹⁵ is hydrogen or C₁-C₄-alkyl, C₁-C₄-alkoxy, nitro, cyano, halogen or phenyl.
 7. The compound I defined in claim 1 wherein R³ is hydrogen, halogen, C₁-C₄-alkyl, C₁-C₄-haloalkyl, nitro, C₁-C₄-alkoxy, C₁-C₄-alkylthio, cyano, amino, methylamino, hydroxyl or dimethylamino.
 8. The compound I defined in claim 1 wherein R⁴ is phenyl which is unsubstituted or carries one or more of the following radicals: halogen, C₁-C₄-alkyl, C₁-C₄-alkoxy and phenyl, or R⁴ and R⁵ are each phenyl groups which are connected to each other in the ortho positions by a direct linkage, a methylene or ethylene group, or an oxygen atom.
 9. The compound I defined in claim 1 wherein R⁵ is phenyl which is unsubstituted or carries one or more of the following radicals: halogen, C₁-C₄-alkyl, C₁-C₄-alkoxy, phenyl and, bonded to two adjacent carbon ring members of the phenyl ring, 1,3-dioxomethylene and 1,4-dioxoethylene.
 10. The compound I defined in claim 1 wherein R⁶ is hydrogen or C₁-C₄-alkyl.
 11. The compound I defined in claim 1 wherein Z is a single bond, oxygen or sulfur.
 12. The compound I defined in claim 1 wherein R⁷ is hydrogen or C₁-C₄-alkyl.
 13. The compound I defined in claim 1 wherein R⁸ is hydrogen or C₁-C₄-alkyl.
 14. The compound I defined in claim 1 wherein R² is hydrogen, chlorine, methyl, ethyl, trifluoromethyl, nitro, methoxy, ethoxy, hydroxyl, methylthio, amino, methylamino or dimethylamino.
 15. The compound I defined in claim 1 wherein X is CR¹⁵ and R¹⁵ is hydrogen, methyl, nitro or cyano.
 16. The compound I defined in claim 1 wherein R³ is hydrogen, chlorine, methyl, ethyl, trifluoromethyl, nitro, methoxy, ethoxy, hydroxyl, methylthio, amino, methylamino or dimethylamino.
 17. The compound I defined in claim 1 wherein R⁴ is phenyl which is unsubstituted or carries one or two methoxy groups, or R⁴ and R⁵ are each phenyl groups which are connected to each other in the ortho positions by a direct linkage, a methylene or ethylene group.
 18. The compound I defined in claim 1 wherein R⁵ is phenyl which is unsubstituted or carries one or two of the following: methoxy, 1,3-dioxomethylene or 1,4-dioxoethylene, or R⁵ is phenyl which is unsubstituted or carries one or two of the following: methoxy, 1,3-dioxomethylene or 1,4-dioxoethylene, which phenyl ring is bonded in the ortho position to R⁸ to form a 6-membered ring wherein Q denotes a direct bond and R⁸ denotes CHR¹⁷.
 19. The compound I defined in claim 1 wherein R⁶ is hydrogen, methyl, ethyl, n-propyl or 1-methylethyl.
 20. The compound I defined in claim 1 wherein R⁷ is hydrogen or methyl.
 21. The compound I defined in claim 1 wherein R⁸ is hydrogen, methyl or 1,1-dimethylethyl.
 22. The compound I defined in claim 1 wherein R⁵ is one of the following radicals


23. The compound I defined in claim 1 wherein R¹⁵ is hydrogen. 